| Gene Symbol | KATNB1 |
|---|---|
| Entrez Gene | 10300 |
| Alt Symbol | KAT, LIS6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | katanin p80 (WD repeat containing) subunit B 1 |
| Other Description | katanin (80 kDa)|katanin p80 (WD40-containing) subunit B 1|katanin p80 WD40 repeat-containing subunit B1|katanin p80 WD40-containing subunit B1|katanin p80 subunit B1|p80 katanin |
| Swissprots | A6NCG6 O60620 Q9BVA0 |
| Accessions | EAW82950 EAW82951 EAW82952 Q9BVA0 AB209250 BAD92487 AF052432 AAC09328 BC001353 AAH01353 BT007022 AAP35668 BU501165 CA306372 CR456762 CAG33043 DQ890767 ABM81693 XM_005255772 XP_005255829 XM_006721121 XP_006721184 XM_006721122 XP_006721185 XM_006721123 XP_006721186 XM_011522810 XP_011521112 NM_005886 NP_005877 |
| Function | Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03022}. |
| Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles. |
Katanin p80 B1 CRISPR/Cas9 KO Plasmid (h) - sc-404520 from Santa Cruz Biotechnology
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Katanin p80 B1 HDR Plasmid (h) - sc-404520-HDR from Santa Cruz Biotechnology
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Katanin p80 B1 Double Nickase Plasmid (h) - sc-404520-NIC from Santa Cruz Biotechnology
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Katanin p80 B1 Double Nickase Plasmid (h2) - sc-404520-NIC-2 from Santa Cruz Biotechnology
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Katanin p80 B1 CRISPR Activation Plasmid (h) - sc-404520-ACT from Santa Cruz Biotechnology
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Katanin p80 B1 CRISPR Activation Plasmid (h2) - sc-404520-ACT-2 from Santa Cruz Biotechnology
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Katanin p80 B1 Lentiviral Activation Particles (h) - sc-404520-LAC from Santa Cruz Biotechnology
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Katanin p80 B1 Lentiviral Activation Particles (h2) - sc-404520-LAC-2 from Santa Cruz Biotechnology
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Katanin p80 B1 siRNA (h) - sc-93267 from Santa Cruz Biotechnology
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Katanin p80 B1 shRNA Plasmid (h) - sc-93267-SH from Santa Cruz Biotechnology
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Katanin p80 B1 shRNA (h) Lentiviral Particles - sc-93267-V from Santa Cruz Biotechnology
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katanin-p80 RNAi - H00010300-R01 from Novus Biologicals
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MISSION® esiRNA - EHU135851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10901 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01908 from Sigma-Aldrich
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KATNB1 siRNA (Human) - CRH6980 from Cohesion Biosciences
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KATNB1, siRNA - MBS8219210 from MyBioSource
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shRNA set against Human KATNB1 (NM_005886.2) - SHH322499 from Creative biogene
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shRNA set against Human KATNB1(NM_005886.2) - SHL187632 from Creative biogene
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Human KATNB1 siRNA - orb267482 from Biorbyt
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KATNB1 shRNA Plasmid (Human) - CHH6980 from Cohesion Biosciences
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KATNB1 miRNA 3'UTR clone - MiUTR1H-05086 from Creative biogene
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