Gene Symbol | VNN1 |
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Entrez Gene | 8876 |
Alt Symbol | HDLCQ8, Tiff66 |
Species | Human |
Gene Type | protein-coding |
Description | vanin 1 |
Other Description | pantetheinase|pantetheine hydrolase|vanin-1|vannin 1|vascular non-inflammatory molecule 1 |
Swissprots | O95497 Q4VAS8 Q4JFW6 Q4VAS7 A8K310 Q4VAS9 Q9UJF4 Q9UF16 |
Accessions | AAY88742 EAW48020 O95497 AJ132099 CAA10568 AK095461 AK290425 BAF83114 AK314265 BAG36929 BC096265 AAH96265 BC096266 AAH96266 BC096267 AAH96267 BC096268 AAH96268 BJ995136 U39664 AAF21453 NM_004666 NP_004657 |
Function | Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. {ECO:0000269|PubMed:10567687, ECO:0000269|PubMed:11491533}. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. |
Tissue Specificity | Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin. {ECO:0000269|PubMed:19322213}. |
Top Pathways | Pantothenate and CoA biosynthesis |
vanin-1 CRISPR/Cas9 KO Plasmid (h) - sc-406512 from Santa Cruz Biotechnology
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vanin-1 HDR Plasmid (h) - sc-406512-HDR from Santa Cruz Biotechnology
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vanin-1 Double Nickase Plasmid (h) - sc-406512-NIC from Santa Cruz Biotechnology
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vanin-1 Double Nickase Plasmid (h2) - sc-406512-NIC-2 from Santa Cruz Biotechnology
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vanin-1 CRISPR Activation Plasmid (h) - sc-406512-ACT from Santa Cruz Biotechnology
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vanin-1 CRISPR Activation Plasmid (h2) - sc-406512-ACT-2 from Santa Cruz Biotechnology
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vanin-1 Lentiviral Activation Particles (h) - sc-406512-LAC from Santa Cruz Biotechnology
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vanin-1 Lentiviral Activation Particles (h2) - sc-406512-LAC-2 from Santa Cruz Biotechnology
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vanin-1 siRNA (h) - sc-36807 from Santa Cruz Biotechnology
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vanin-1 shRNA Plasmid (h) - sc-36807-SH from Santa Cruz Biotechnology
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vanin-1 shRNA (h) Lentiviral Particles - sc-36807-V from Santa Cruz Biotechnology
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Vanin-1/VNN1 RNAi - H00008876-R01 from Novus Biologicals
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MISSION® esiRNA - EHU021601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22699 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22699 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10136 from Sigma-Aldrich
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VNN1 siRNA (Human) - CRH5863 from Cohesion Biosciences
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VNN1 - MBS8215772 from MyBioSource
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vanin-1 CRISPR/Cas9 KO Plasmid (h2) - sc-406512-KO-2 from Santa Cruz Biotechnology
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vanin-1 HDR Plasmid (h2) - sc-406512-HDR-2 from Santa Cruz Biotechnology
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Human VNN1 siRNA - orb266365 from Biorbyt
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VNN1 shRNA Plasmid (Human) - CHH5863 from Cohesion Biosciences
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