| Gene Symbol |
CDK13
|
| Entrez Gene |
8621
|
| Alt Symbol |
CDC2L, CDC2L5, CHED, hCDK13
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin-dependent kinase 13
|
| Other Description |
CDC2-related protein kinase 5|cell division cycle 2-like protein kinase 5|cell division protein kinase 13|cholinesterase-related cell division controller
|
| Swissprots |
Q9H4A0 Q75MH5 Q9UDR4 Q96JN4 Q14004 Q6DKQ9 Q9H4A1 Q53G78 Q75MH4
|
| Accessions |
AAD54514 AAS07490 AAS07491 AAT74623 EAW94128 EAW94129 EAW94130 EAW94131 EAW94132 EAW94133 Q14004 AB058694 BAB47420 AJ297709 CAC10400 AJ297710 CAC10401 AK025500 AK092534 AK130653 AK223053 BAD96773 BC001274 AAH01274 BC080601 BC168380 AAI68380 BF707421 BM699295 BM727913 BU686489 BX647326 CR748837 M80629 AAA58424 XM_011515597 XP_011513899 XM_011515598 XP_011513900 NM_003718 NP_003709 NM_031267 NP_112557
|
| Function |
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys- 51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
|
| Subcellular Location |
Nucleus speckle {ECO:0000269|PubMed:16721827}.
|
| Tissue Specificity |
Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.
|