CDK13

Gene Symbol	CDK13
Entrez Gene	8621
Alt Symbol	CDC2L, CDC2L5, CHED, hCDK13
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 13
Other Description	CDC2-related protein kinase 5|cell division cycle 2-like protein kinase 5|cell division protein kinase 13|cholinesterase-related cell division controller
Swissprots	Q9H4A0 Q75MH5 Q9UDR4 Q96JN4 Q14004 Q6DKQ9 Q9H4A1 Q53G78 Q75MH4
Accessions	AAD54514 AAS07490 AAS07491 AAT74623 EAW94128 EAW94129 EAW94130 EAW94131 EAW94132 EAW94133 Q14004 AB058694 BAB47420 AJ297709 CAC10400 AJ297710 CAC10401 AK025500 AK092534 AK130653 AK223053 BAD96773 BC001274 AAH01274 BC080601 BC168380 AAI68380 BF707421 BM699295 BM727913 BU686489 BX647326 CR748837 M80629 AAA58424 XM_011515597 XP_011513899 XM_011515598 XP_011513900 NM_003718 NP_003709 NM_031267 NP_112557
Function	Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys- 51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269|PubMed:16721827, ECO:0000269|PubMed:1731328, ECO:0000269|PubMed:18480452, ECO:0000269|PubMed:20952539}.
Subcellular Location	Nucleus speckle {ECO:0000269|PubMed:16721827}.
Tissue Specificity	Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CDC2L5 full length protein - ab160114 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human CDC2L5 protein fragment - ab160115 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CDK13 / CDC2L5 Antibody Blocking Peptide - LS-E3742 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CDC2L5 Protein - H00008621-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CDC2L5 Protein - H00008621-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CDC2L5 Peptide - P2517 from Novus Biologicals Category Peptide Species Human

CDC2L5-Antibody-N-term-Blocking-Peptide - BP7514a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CDK13 / CDC2L5 - H00008621-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CDK13 / CDC2L5 - H00008621-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CDK13 / CDC2L5 - H00008621-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CDK13 / CDC2L5 - H00008621-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human Cyclin-dependent kinase 13(CDK13) ,partial - CSB-YP613482HU CSB-EP613482HU CSB-BP613482HU CSB-MP613482HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Human CDC2L5 protein fragment - ab204099 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human CDK13 + CyclinK protein fragment - ab204098 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Recombinant Human CDK13/Cyclin K protein, GST-tagged - CDK13-01H from Creative Biomart Category Protein Source Insect cells Species Human

Recombinant Human CDK13 protein, GST-tagged - CDK13-02H from Creative Biomart Category Protein Source Insect cells Species Human

CDC2L5 Recombinant Protein Antigen - NBP2-34123PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CDK13 Peptide, Human - M34GP02862H from Creative Peptides Category Peptide Source Synthetic. Species Human

Cyclin-dependent kinase 13 (CDK13), partial, Recombinant Protein - MBS1306830 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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