| Gene Symbol |
RAB3GAP1
|
| Entrez Gene |
22930
|
| Alt Symbol |
P130, RAB3GAP, RAB3GAP130, WARBM1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB3 GTPase activating protein subunit 1 (catalytic)
|
| Other Description |
RAB3 GTPase-activating protein 130 kDa subunit|rab3 GTPase-activating protein catalytic subunit|rab3-GAP p130
|
| Swissprots |
Q15042 A6H8Z3 Q8TBB4 Q659F5 C9J837
|
| Accessions |
EAX11637 EAX11638 EAX11639 EAX11640 EAX11641 Q15042 AB449877 BAH16620 AK022494 AK056058 AK309118 AL096752 CAH56411 BC020303 BC022977 AAH22977 BC030992 BC036732 BC071602 BC146809 AAI46810 BP872264 D31886 BAA06684 DA333844 XM_011510822 XP_011509124 XM_011510823 XP_011509125 XM_011510824 XP_011509126 XM_011510825 XP_011509127 NM_001172435 NP_001165906 NM_012233 NP_036365
|
| Function |
Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. {ECO:0000269|PubMed:10859313, ECO:0000269|PubMed:9030515}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9852129}. Note=In neurons, it is enriched in the synaptic soluble fraction.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:9030515}.
|