Gene Symbol | RAB3GAP1 |
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Entrez Gene | 22930 |
Alt Symbol | P130, RAB3GAP, RAB3GAP130, WARBM1 |
Species | Human |
Gene Type | protein-coding |
Description | RAB3 GTPase activating protein subunit 1 (catalytic) |
Other Description | RAB3 GTPase-activating protein 130 kDa subunit|rab3 GTPase-activating protein catalytic subunit|rab3-GAP p130 |
Swissprots | Q15042 A6H8Z3 Q8TBB4 Q659F5 C9J837 |
Accessions | EAX11637 EAX11638 EAX11639 EAX11640 EAX11641 Q15042 AB449877 BAH16620 AK022494 AK056058 AK309118 AL096752 CAH56411 BC020303 BC022977 AAH22977 BC030992 BC036732 BC071602 BC146809 AAI46810 BP872264 D31886 BAA06684 DA333844 XM_011510822 XP_011509124 XM_011510823 XP_011509125 XM_011510824 XP_011509126 XM_011510825 XP_011509127 NM_001172435 NP_001165906 NM_012233 NP_036365 |
Function | Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. {ECO:0000269|PubMed:10859313, ECO:0000269|PubMed:9030515}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:9852129}. Note=In neurons, it is enriched in the synaptic soluble fraction. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:9030515}. |
Rab 3 GAP p130 CRISPR/Cas9 KO Plasmid (h) - sc-417558 from Santa Cruz Biotechnology
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Rab 3 GAP p130 HDR Plasmid (h) - sc-417558-HDR from Santa Cruz Biotechnology
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Rab 3 GAP p130 Double Nickase Plasmid (h) - sc-417558-NIC from Santa Cruz Biotechnology
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Rab 3 GAP p130 Double Nickase Plasmid (h2) - sc-417558-NIC-2 from Santa Cruz Biotechnology
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Rab 3 GAP p130 CRISPR Activation Plasmid (h) - sc-417558-ACT from Santa Cruz Biotechnology
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Rab 3 GAP p130 CRISPR Activation Plasmid (h2) - sc-417558-ACT-2 from Santa Cruz Biotechnology
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Rab 3 GAP p130 Lentiviral Activation Particles (h) - sc-417558-LAC from Santa Cruz Biotechnology
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Rab 3 GAP p130 Lentiviral Activation Particles (h2) - sc-417558-LAC-2 from Santa Cruz Biotechnology
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Rab 3 GAP p130 siRNA (h) - sc-94704 from Santa Cruz Biotechnology
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Rab 3 GAP p130 shRNA Plasmid (h) - sc-94704-SH from Santa Cruz Biotechnology
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Rab 3 GAP p130 shRNA (h) Lentiviral Particles - sc-94704-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU053091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17846 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17846 from Sigma-Aldrich
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RAB3GAP1 siRNA (Human) - CRH7881 from Cohesion Biosciences
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RAB3GAP1 - MBS8221019 from MyBioSource
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shRNA set against Human Rab3gap1 (NM_012233.2) - SHH388348 from Creative biogene
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Human RAB3GAP1 siRNA - orb268383 from Biorbyt
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RAB3GAP1 shRNA Plasmid (Human) - CHH7881 from Cohesion Biosciences
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RAB3GAP1 miRNA 3'UTR clone - MiUTR3H-05069 from Creative biogene
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