Gene Symbol | THOP1 |
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Entrez Gene | 7064 |
Alt Symbol | EP24.15, MEPD_HUMAN, MP78, TOP |
Species | Human |
Gene Type | protein-coding |
Description | thimet oligopeptidase 1 |
Other Description | endopeptidase 24.15|thimet oligopeptidase |
Swissprots | B3KSE2 P52888 Q9UCB3 |
Accessions | AAA82606 AAD13118 CBG17384 CBV30826 EAW69364 EAW69365 P52888 AK093392 BAG52704 AK300552 BAG62258 BC000135 AAH00135 BC000583 AAH00583 BC002391 AAH02391 BC013878 AAH13878 BC067281 EU176234 ABW03685 U29366 AAA82607 Z50115 CAA90477 XM_011528228 XP_011526530 NM_003249 NP_003240 |
Function | Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. |
Subcellular Location | Cytoplasm. |
Top Pathways | African trypanosomiasis, Renin-angiotensin system |
Thimet Oligopeptidase CRISPR/Cas9 KO Plasmid (h) - sc-404951 from Santa Cruz Biotechnology
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Thimet Oligopeptidase HDR Plasmid (h) - sc-404951-HDR from Santa Cruz Biotechnology
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Thimet Oligopeptidase Double Nickase Plasmid (h) - sc-404951-NIC from Santa Cruz Biotechnology
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Thimet Oligopeptidase Double Nickase Plasmid (h2) - sc-404951-NIC-2 from Santa Cruz Biotechnology
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Thimet Oligopeptidase CRISPR Activation Plasmid (h) - sc-404951-ACT from Santa Cruz Biotechnology
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Thimet Oligopeptidase CRISPR Activation Plasmid (h2) - sc-404951-ACT-2 from Santa Cruz Biotechnology
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Thimet Oligopeptidase Lentiviral Activation Particles (h) - sc-404951-LAC from Santa Cruz Biotechnology
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Thimet Oligopeptidase Lentiviral Activation Particles (h2) - sc-404951-LAC-2 from Santa Cruz Biotechnology
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Thimet oligopeptidase siRNA (h) - sc-72152 from Santa Cruz Biotechnology
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Thimet oligopeptidase shRNA Plasmid (h) - sc-72152-SH from Santa Cruz Biotechnology
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Thimet oligopeptidase shRNA (h) Lentiviral Particles - sc-72152-V from Santa Cruz Biotechnology
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Thimet Oligopeptidase/THOP1 RNAi - H00007064-R01 from Novus Biologicals
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MISSION® esiRNA - EHU136881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21321 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02480 from Sigma-Aldrich
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THOP1 siRNA (Human) - CRH4834 from Cohesion Biosciences
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THOP1 - MBS8204299 from MyBioSource
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shRNA set against Human THOP1(NM_003249.3) - SHL069546 from Creative biogene
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Human THOP1 siRNA - orb265336 from Biorbyt
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THOP1 shRNA Plasmid (Human) - CHH4834 from Cohesion Biosciences
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THOP1 miRNA 3'UTR clone - MiUTR3H-03888 from Creative biogene
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