| Gene Symbol | SFN |
|---|---|
| Entrez Gene | 2810 |
| Alt Symbol | YWHAS |
| Species | Human |
| Gene Type | protein-coding |
| Description | stratifin |
| Other Description | 14-3-3 protein sigma|14-3-3 sigma|epithelial cell marker protein 1 |
| Swissprots | Q6FH51 Q96DH0 P31947 Q6FH30 |
| Accessions | AAC52029 EAX07786 EAX07787 P31947 AF029082 AAC52030 BC000329 AAH00329 BC000995 AAH00995 BC001550 AAH01550 BC002995 AAH02995 BC023552 AAH23552 CR541905 CAG46703 CR541926 CAG46724 DQ894162 ABM85088 M93010 AAA59546 NM_006142 NP_006133 |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. {ECO:0000269|PubMed:18382127}. |
| Subcellular Location | Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway. |
| Tissue Specificity | Present mainly in tissues enriched in stratified squamous keratinizing epithelium. |
| Top Pathways | Cell cycle, p53 signaling pathway, Aldosterone-regulated sodium reabsorption |