SFN

Gene Symbol	SFN
Entrez Gene	2810
Alt Symbol	YWHAS
Species	Human
Gene Type	protein-coding
Description	stratifin
Other Description	14-3-3 protein sigma|14-3-3 sigma|epithelial cell marker protein 1
Swissprots	Q6FH51 Q96DH0 P31947 Q6FH30
Accessions	AAC52029 EAX07786 EAX07787 P31947 AF029082 AAC52030 BC000329 AAH00329 BC000995 AAH00995 BC001550 AAH01550 BC002995 AAH02995 BC023552 AAH23552 CR541905 CAG46703 CR541926 CAG46724 DQ894162 ABM85088 M93010 AAA59546 NM_006142 NP_006133
Function	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. {ECO:0000269|PubMed:18382127}.
Subcellular Location	Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.
Tissue Specificity	Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Top Pathways	Cell cycle, p53 signaling pathway, Aldosterone-regulated sodium reabsorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SFN-cDNA-Clone - DC00726 from Abgent, a WuXi AppTec company Prices $334.80 Sizes 10 µg Species Human Accession BC000329

SFN cDNA (ANA11757) - ANA11757 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC001550

SFN - MBS1267989 from MyBioSource Species Human Accession BC001550

SFN - MBS1274690 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC000329

Human SFN cDNA clone(NM_006142.3) - CDFH017363 from Creative Biomart Species Human Accession NM_006142.3

Human SFN ORF clone(NM_006142.3) - CDCL186156 from Creative Biomart Species Human Accession NM_006142.3

Human SFN ORF Clone(NM_006142.3) - CDCR292067 from Creative Biomart Species Human Accession NM_006142.3

Human SFN ORF Clone(NM_006142.3) - CDCR292068 from Creative Biomart Species Human Accession NM_006142.3

Human SFN ORF Clone(NM_006142.3) - CDCR292069 from Creative Biomart Species Human Accession NM_006142.3

Human SFN ORF Clone(NM_006142.3) - CDCL175210 from Creative Biomart Species Human Accession NM_006142.3

Human SFN ORF Clone(NM_006142.3) - CDCL175211 from Creative Biomart Species Human Accession NM_006142.3

human SFN ORF clone - CDCH079218 from Creative Biomart Species Human Accession NM_006142

human SFN ORF clone - CDCH079219 from Creative Biomart Species Human Accession NM_006142

human SFN ORF clone - CDCH079220 from Creative Biomart Species Human Accession NM_006142

human SFN ORF clone - CDCH079221 from Creative Biomart Species Human Accession NM_006142

human SFN ORF clone - CDCH079222 from Creative Biomart Species Human Accession NM_006142

human SFN ORF clone - CDCH079223 from Creative Biomart Species Human Accession NM_006142

Human SFN Gene cDNA clone plasmid - HG10838-M from Sino Biological Species Human

Human 14-3-3 sigma/Stratifin/YWHAS Gene ORF cDNA clone expression plasmid, C-His tag - HG10838-CH from Sino Biological Species Human

Human 14-3-3 sigma/Stratifin/YWHAS Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10838-M-F from Sino Biological Species Human

Human SFN Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG10838-M-N from Sino Biological Species Human Accession NM_006142.3

Human 14-3-3 sigma/Stratifin/YWHAS Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10838-ACR from Sino Biological Species Human

Human 14-3-3 sigma/Stratifin/YWHAS Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10838-ANR from Sino Biological Species Human

Human 14-3-3 sigma/Stratifin/YWHAS Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10838-ACG from Sino Biological Species Human

Human 14-3-3 sigma/Stratifin/YWHAS Gene ORF cDNA clone expression plasmid - HG10838-UT from Sino Biological Species Human

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