SFN

Gene Symbol SFN
Entrez Gene 2810
Alt Symbol YWHAS
Species Human
Gene Type protein-coding
Description stratifin
Other Description 14-3-3 protein sigma|14-3-3 sigma|epithelial cell marker protein 1
Swissprots Q6FH51 Q96DH0 P31947 Q6FH30
Accessions AAC52029 EAX07786 EAX07787 P31947 AF029082 AAC52030 BC000329 AAH00329 BC000995 AAH00995 BC001550 AAH01550 BC002995 AAH02995 BC023552 AAH23552 CR541905 CAG46703 CR541926 CAG46724 DQ894162 ABM85088 M93010 AAA59546 NM_006142 NP_006133
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. {ECO:0000269|PubMed:18382127}.
Subcellular Location Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.
Tissue Specificity Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Top Pathways Cell cycle, p53 signaling pathway, Aldosterone-regulated sodium reabsorption

14-3-3 σ (N-14) - sc-7681 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
14-3-3 σ (N-14): sc-7681. Western blot analysis of 114-3-3 σ expression in HeLa nuclear extract.

14-3-3 σ (C-18) - sc-7683 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
14-3-3 σ (C-18): sc-7683. Western blot analysis of 14-3-3 σexpression in HeLa nuclear extract.

14-3-3 σ (E-11) - sc-166473 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
14-3-3 σ (E-11): sc-166473. Western blot analysis of 14-3-3 σ expression in non-transfected 293T: sc-117752 (A), human 14-3-3 σ transfected 293T: sc-110782 (B) and A-431 (C) whole cell lysates.

14-3-3 σ (5D7) - sc-100638 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
14-3-3 σ (5D7): sc-100638. Western blot analysis of 14-3-3 σ expression in HeLa nuclear extract.

Anti-14-3-3 sigma antibody - ab151504 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-14-3-3 sigma antibody (ab151504) at 1/3000 dilutionLane 1 : Neuro2A whole cell lysateLane 2 : GL261 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-14-3-3 sigma antibody - ab86380 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling 14-3-3 sigma with ab86380 at 1/1000 (1µg/ml). Detection: DAB.

Anti-14-3-3 sigma antibody - ab89405 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-14-3-3 sigma antibody (ab89405) at 5 µg/ml + Human ovary cancer tissue lysate at 50 µg

Anti-14-3-3 sigma antibody - ab89510 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-14-3-3 sigma antibody (ab89510) at 5 µg/ml + Tagged recombinant Human 14-3-3 sigma protein at 0.2 µg

Anti-14-3-3 sigma antibody [1.N.6] - ab14123 from Abcam

Prices $400.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 1.N.6
ab14123 staining mouse embryonic skin tissue sections by IHC-P.  Sections were PFA fixed and subjected to heat mediated antigen retrieval in citrate buffer prior to blocking with a commercially available (mouse-on-mouse) blocking reagent for 1 hour at RT.  The primary antibody was diluted 1/50 and incubated with the sample for 24 hours at 4°C.   A biotinylated mouse anti-mouse antibody was used as the secondary, followed by a Streptavidin-Cy3®.  See Abreview

Anti-14-3-3 sigma antibody [1.N.6] - ab14116 from Abcam

Prices $373.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1.N.6

Anti-14-3-3 sigma antibody [1.T.28] - ab14122 from Abcam

Prices $372.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1.T.28

Anti-14-3-3 sigma antibody [1433S01] - ab76532 from Abcam

Prices $372.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1433S01

Anti-14-3-3 sigma antibody [EPR5873(2)] - ab193667 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5873(2)
All lanes : Anti-14-3-3 sigma antibody [EPR5873(2)] (ab193667) at 1/1000 dilutionLane 1 : Human skin lysateLane 2 : A431 cell lysateLane 3 : HACAT cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-14-3-3 sigma antibody [SPM159], prediluted - ab53913 from Abcam

Host Mouse
Clonality Monoclonal
Clone SPM159
ab53913 staining 14-3-3 sigma in human skin tissue; formalin fixed, paraffin embedded section.

Anti-SFN / Stratifin / 14-3-3 Sigma Antibody - LS-C34770 from LifeSpan Bioscience

Prices $560.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-SFN / Stratifin / 14-3-3 Sigma Antibody - LS-C34771 from LifeSpan Bioscience

Prices $455.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal

Anti-SFN / Stratifin / 14-3-3 Sigma Antibody (aa1-248) - LS-C39288 from LifeSpan Bioscience

Prices $475.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-SFN / Stratifin / 14-3-3 Sigma Antibody (clone 1433S01) - LS-C85422 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1433S01

Anti-SFN / Stratifin / 14-3-3 Sigma Antibody (aa1-249, Azide-free) - LS-C122452 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-SFN / Stratifin / 14-3-3 Sigma Antibody - LS-C132267 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SFN / Stratifin / 14-3-3 Sigma Antibody (clone 1433S01, Azide-free) - LS-C87600 from LifeSpan Bioscience

Prices $610.00, $995.00
Sizes 100 µl, 200 µl
Host Mouse
Clonality Monoclonal
Clone 1433S01
Formalin-fixed, paraffin-embedded human skin stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of epidermis.

Anti-SFN / Stratifin / 14-3-3 Sigma Antibody (C-Terminus) - LS-C144836 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SFN / Stratifin / 14-3-3 Sigma Antibody (phospho-Ser248) - LS-C144998 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SFN / Stratifin / 14-3-3 Sigma Antibody (Internal, clone EPR5872) - LS-C138801 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5872
Western blot analysis on (A) fetal lung, (B) A549, (C) human kidney, and (D) human spleen lysates using anti-14-3-3 sigma antibody.

Anti-SFN / Stratifin / 14-3-3 Sigma Antibody (clone LG.3A10) - LS-C188843 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone LG.3A10
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