CASP3

Gene Symbol	CASP3
Entrez Gene	836
Alt Symbol	CPP32, CPP32B, SCA-1
Species	Human
Gene Type	protein-coding
Description	caspase 3, apoptosis-related cysteine peptidase
Other Description	CASP-3|CPP-32|PARP cleavage protease|SREBP cleavage activity 1|apopain|caspase 3, apoptosis-related cysteine protease|caspase-3|cysteine protease CPP32|procaspase3|protein Yama
Swissprots	Q96AN1 Q96KP2 D3DP53 P42574 A8K5M2
Accessions	AAO25654 CAG17895 CAV28500 CBX53863 CBX53864 EAX04673 EAX04674 EAX04675 EAX04676 P42574 AJ413269 CAC88866 AK291337 BAF84026 AU127028 AU133051 BC016926 AAH16926 BU753483 BX647609 CAI46084 DQ891543 ABM82469 DQ894731 ABM85657 U13737 AAA65015 U13738 AAB60355 U26943 AAA74929 XM_011532301 XP_011530603 NM_004346 NP_004337 NM_032991 NP_116786
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. {ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:7596430}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Top Pathways	TNF signaling pathway, Apoptosis, Viral carcinogenesis, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-CASP3-cDNA-Clone - DC04387 from Abgent, a WuXi AppTec company Prices $373.95 Sizes 10 µg Species Human Accession BC016926

CASP3 - MBS1274129 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC016926

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone in cloning vector - HG10050-M from Sino Biological Species Human

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-HA tag - HG10050-CY from Sino Biological Species Human

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-His tag - HG10050-CH from Sino Biological Species Human

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone expression plasmid - HG10050-UT from Sino Biological Species Human

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-HA tag - HG10050-NY from Sino Biological Species Human

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10050-NF from Sino Biological Species Human

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10050-CF from Sino Biological Species Human

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10050-ACG from Sino Biological Species Human

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10050-NM from Sino Biological Species Human

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10050-CM from Sino Biological Species Human

Human Caspase-3 transcript variant alpha Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10050-M-F from Sino Biological Species Human Accession NM_004346.3

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-His tag - HG10050-NH from Sino Biological Species Human

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10050-ACR from Sino Biological Species Human

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10050-ANR from Sino Biological Species Human

Human caspase-3 / CASP-3 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10050-ANG from Sino Biological Species Human

CASP3 - CL01313H01 from Elabscience Species Human Accession NM_004346.3

CASP3 - CL01313H02 from Elabscience Species Human Accession NM_032991.2

Human Caspase-3 ORF clone(NM_004346.3) - CDCL183059 from Creative biogene Species Human

Human CASP3 ORF Clone(NM_032991.2) - CDCR313215 from Creative biogene Species Human

Human CASP3 ORF Clone (BC016926) - CDCS411744 from Creative biogene Species Human Accession P42574

Human CASP3 cDNA Clone(NM_032991.2) - CDFG006514 from Creative biogene Species Human

Human CASP3 cDNA Clone(NM_032991.2) - CDFG006516 from Creative biogene Species Human

Human CASP3 cDNA Clone(NM_032991.2) - CDFG006517 from Creative biogene Species Human

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