CASP3

Gene Symbol	CASP3
Entrez Gene	836
Alt Symbol	CPP32, CPP32B, SCA-1
Species	Human
Gene Type	protein-coding
Description	caspase 3, apoptosis-related cysteine peptidase
Other Description	CASP-3|CPP-32|PARP cleavage protease|SREBP cleavage activity 1|apopain|caspase 3, apoptosis-related cysteine protease|caspase-3|cysteine protease CPP32|procaspase3|protein Yama
Swissprots	Q96AN1 Q96KP2 D3DP53 P42574 A8K5M2
Accessions	AAO25654 CAG17895 CAV28500 CBX53863 CBX53864 EAX04673 EAX04674 EAX04675 EAX04676 P42574 AJ413269 CAC88866 AK291337 BAF84026 AU127028 AU133051 BC016926 AAH16926 BU753483 BX647609 CAI46084 DQ891543 ABM82469 DQ894731 ABM85657 U13737 AAA65015 U13738 AAB60355 U26943 AAA74929 XM_011532301 XP_011530603 NM_004346 NP_004337 NM_032991 NP_116786
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. {ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:7596430}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Top Pathways	TNF signaling pathway, Apoptosis, Viral carcinogenesis, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Cleaved Caspase-3 (Asp175) Sandwich ELISA Kit - 7190 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

Caspase-3 Activity Assay Kit - 5723 from Cell Signaling Technology Category Assay Kit Prices $524.00 Sizes 1 kit (200 assays)

Active Caspase 3 (Asp175) Human ELISA Kit - ab168541 from Abcam Category ELISA Kit Sensitivity 2 µg/ml Range Sample specific recoverySample typeAverage %RangeCell culture media10498% - 109%Extraction Buffer107106% - 109%Goat Serum9392% - 93%

Active Caspase 3 (Ser29) Human ELISA Kit - ab154469 from Abcam Category ELISA Kit Sensitivity = 3 ng/ml

Active Caspase 3 (Ser29) Human SimpleStep ELISA™ Kit - ab181418 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 58 pg/ml Range 0.16 ng/ml - 20 ng/ml

Pro and Active Caspase 3 DUPLEX Human ELISA Kit  (Fluorescent) - ab173187 from Abcam Category ELISA Kit Range Sample specific recoverySample typeAverage %RangeCell culture media105105% - 106%Extraction Buffer115113% - 116%Goat Serum6966% - 71%

Pro Caspase 3 Human ELISA Kit - ab151283 from Abcam Category ELISA Kit Sensitivity = 4 µg/ml Range Sample specific recoverySample typeAverage %RangeSerum= 8481% - 86%Cell culture media= 9693% - 99%Extraction Buffer= 114108% - 120%

Pro Caspase 3 Human SimpleStep ELISA™ Kit - ab192146 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 3 pg/ml Range 0.156 ng/ml - 10 ng/ml

Human CASP3 / Caspase 3 ELISA Kit (Sandwich ELISA) - LS-F4137 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Rat CASP3 / Caspase 3 ELISA Kit (Sandwich ELISA) - LS-F4138 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse CASP3 / Caspase 3 ELISA Kit (Sandwich ELISA) - LS-F4139 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.244 ng/ml Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-CASP3 / Caspase 3 (Ser150) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1328 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat CASP3 / Caspase 3 ELISA Kit (Cell-Based ELISA) - LS-F1854 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Bovine CASP3 / Caspase 3 ELISA Kit (Sandwich ELISA) - LS-F8812 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.053 ng/ml Range 0.156-10 ng/ml

Rat CASP3 / Caspase 3 ELISA Kit (Sandwich ELISA) - LS-F11016 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Pig CASP3 / Caspase 3 ELISA Kit (Sandwich ELISA) - LS-F11017 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Mouse CASP3 / Caspase 3 ELISA Kit (Sandwich ELISA) - LS-F11015 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Rabbit CASP3 / Caspase 3 ELISA Kit - LS-F11018 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.312 Range 0.312 - 20 ng/ml

Human CASP3 / Caspase 3 ELISA Kit (Sandwich ELISA) - LS-F11014 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.31 ng/ml Range 0.156-10 ng/ml

Bovine CASP3 / Caspase 3 ELISA Kit (Sandwich ELISA) - LS-F11013 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.78 Range 0.156-10 ng/ml

Caspase-3 Fluorometric Assay Kit - KA0744 from Novus Biologicals Category Assay Kit Prices $659.00 Sizes 1 kit

Caspase-3 Fluorometric Assay Kit - KA0743 from Novus Biologicals Category Assay Kit Prices $659.00 Sizes 1 kit

Caspase-3 Fluorometric Assay Kit - KA0742 from Novus Biologicals Category Assay Kit Prices $659.00 Sizes 1 kit

Caspase-3 Fluorometric Assay Kit - KA0741 from Novus Biologicals Category Assay Kit Prices $519.00 Sizes 1 kit

Caspase-3 Colorimetric Assay Kit - KA0740 from Novus Biologicals Category Assay Kit Prices $519.00 Sizes 1 kit

Search more