SGMS2

Gene Symbol	SGMS2
Entrez Gene	166929
Alt Symbol	SMS2
Species	Human
Gene Type	protein-coding
Description	sphingomyelin synthase 2
Other Description	SM synthase|phosphatidylcholine:ceramide cholinephosphotransferase 2
Swissprots	B2RA61 A8K2S9 Q8NHU3
Accessions	EAX06211 EAX06212 EAX06213 Q8NHU3 AF452717 AAP13352 AK290344 BAF83033 AK314049 BAG36758 AL833599 BC028705 AAH28705 BC041369 AAH41369 BX649142 DB048409 DC417367 XM_006714121 XP_006714184 XM_011531698 XP_011530000 XM_011531699 XP_011530001 XM_011531700 XP_011530002 XM_011531701 XP_011530003 XM_011531702 XP_011530004 NM_001136257 NP_001129729 NM_001136258 NP_001129730 NM_152621 NP_689834
Function	Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity. {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly plasma membrane, some in Golgi apparatus. Some localization in the perinuclear region where it colocalizes with a sialyltransferase.
Tissue Specificity	Brain, heart, kidney, liver, muscle and stomach. Also expressed in a number of cell lines such as carcinoma HeLa cells, hepatoma Hep-G2 cells, and colon carcinoma Caco-2 cells. {ECO:0000269|PubMed:14685263}.
Top Pathways	Sphingolipid signaling pathway, Sphingolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Sphingomyelin Synthase 2 full length protein - ab153615 from Abcam Category Protein Source Wheat germ Species Human

Human Sphingomyelin Synthase 2 protein fragment - ab153616 from Abcam Category Protein Source Wheat germ Species Human

SMS2 / SGMS2 Antibody Blocking Peptide - LS-E19135 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMS2 / SGMS2 Antibody Blocking Peptide - LS-E10290 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMS2 / SGMS2 Antibody Blocking Peptide - LS-E10329 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Sphingomyelin Synthase 2 Protein - H00166929-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Sphingomyelin Synthase 2 Protein - H00166929-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

SGMS2-Antibody-C-term-Blocking-Peptide - BP9801b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SGMS2-Antibody-C-term-Blocking-Peptide - BP9740b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human SMS2 (Fc Tag) protein - orb232339 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Species Human

SGMS2 Blocking Peptide - 33R-4378 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SGMS2 Blocking Peptide - 33R-4377 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SGMS2 - H00166929-P02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

SGMS2 - H00166929-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SGMS2 - H00166929-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SGMS2 control peptide - AP05278CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

SGMS2 fusion protein - ag6095 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human SGMS2, His-tagged - SGMS2-2632H from Creative Biomart Category Protein Source E.coli Species Human

Human SMS2 / Sphingomyelin synthase 2 Protein (Fc Tag) - 14738-H04H-20 from Sino Biological Category Protein Prices $138.00, $138.00 Sizes 20 µg, 100 µg Source Human Cells Species Human

Recombinant Human SGMS2 Protein, Fc-tagged - SGMS2-633H from Creative Biomart Category Protein Source HEK293 Species Human

Sphingomyelin Synthase 2 Recombinant Protein Antigen - NBP1-92436PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SGMS2 Peptide, Human - M34GP14141H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human SMS2 / Sphingomyelin synthase 2 Protein (Fc Tag) - 14738-H04H from ABclonal Category Protein Prices $138.00, $348.00 Sizes 20 µg, 100 µg Source Human Cells Species Human

Phosphatidylcholine:ceramide cholinephosphotransferase 2 (SGMS2), Recombinant Protein - MBS7029695 from MyBioSource Category Protein Prices $1,175.00, $2,160.00, $3,365.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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