SGMS2

Gene Symbol SGMS2
Entrez Gene 166929
Alt Symbol SMS2
Species Human
Gene Type protein-coding
Description sphingomyelin synthase 2
Other Description SM synthase|phosphatidylcholine:ceramide cholinephosphotransferase 2
Swissprots B2RA61 A8K2S9 Q8NHU3
Accessions EAX06211 EAX06212 EAX06213 Q8NHU3 AF452717 AAP13352 AK290344 BAF83033 AK314049 BAG36758 AL833599 BC028705 AAH28705 BC041369 AAH41369 BX649142 DB048409 DC417367 XM_006714121 XP_006714184 XM_011531698 XP_011530000 XM_011531699 XP_011530001 XM_011531700 XP_011530002 XM_011531701 XP_011530003 XM_011531702 XP_011530004 NM_001136257 NP_001129729 NM_001136258 NP_001129730 NM_152621 NP_689834
Function Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity. {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly plasma membrane, some in Golgi apparatus. Some localization in the perinuclear region where it colocalizes with a sialyltransferase.
Tissue Specificity Brain, heart, kidney, liver, muscle and stomach. Also expressed in a number of cell lines such as carcinoma HeLa cells, hepatoma Hep-G2 cells, and colon carcinoma Caco-2 cells. {ECO:0000269|PubMed:14685263}.
Top Pathways Sphingolipid signaling pathway, Sphingolipid metabolism

SMS2 (D-14) - sc-34055 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SMS2 (H-55) - sc-366682 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SMS2 (H-55): sc-366682. Western blot analysis of SMS2 expression in Jurkat (A), Hep G2 (B), CCRF-CEM (C), HEK293 (D) and NCI-H460 (E) whole cell lysates and human brain tissue extract (F).

SMS2 (N-13) - sc-34048 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SMS2 (M-18) - sc-103883 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Sphingomyelin Synthase 2 antibody - ab87214 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Sphingomyelin Synthase 2 antibody (ab87214) at 1 µg/ml (in 5% skim milk / PBS buffer) + 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Sphingomyelin Synthase 2 antibody - ab102941 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Sphingomyelin Synthase 2 antibody (ab102941) at 1/100 dilution + HepG2 cell line lysates at 35 µg

Anti-Sphingomyelin Synthase 2 antibody - ab103060 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Sphingomyelin Synthase 2 antibody (ab103060) at 1/100 dilution + CEM cell lysate at 35 µg

Anti-Sphingomyelin Synthase 2 antibody - ab58074 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab58074 Sphingomyelin Synthase 2 antibody at 1ug/ml.

Anti-Sphingomyelin Synthase 2 antibody - C-terminal - ab189443 from Abcam

Prices $407.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Sphingomyelin Synthase 2 antibody - C-terminal (ab189443) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : CEM cell lysateLane 3 : NCI-H460 cell lysateLysates/proteins at 35 µg per lane.

Anti-SMS2 / SGMS2 Antibody (C-Terminus, APC) - LS-C240699 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMS2 / SGMS2 Antibody (C-Terminus, Biotin) - LS-C240700 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMS2 / SGMS2 Antibody (C-Terminus, FITC) - LS-C240701 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMS2 / SGMS2 Antibody - LS-C140519 from LifeSpan Bioscience

Prices $460.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot on human brain lysate (10 ug/lane) using X2059P antibody to Sphingomyelin Synthase 2 (0.5 ug/ml). Lane A] 1 ug/ml antibody alone, lane B] antibody plus 3 ug blocking peptide. Blot was developed with Pierce Super System West Femto - 1 minute exposure.

Anti-SMS2 / SGMS2 Antibody (C-Terminus, AP) - LS-C240702 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMS2 / SGMS2 Antibody (C-Terminus, PE) - LS-C240703 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMS2 / SGMS2 Antibody (aa336-365, AP) - LS-C240704 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMS2 / SGMS2 Antibody (aa71-120) - LS-C102513 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SGMS2 antibody LS-C102513 Western blot of Fetal Heart lysate.

Anti-SMS2 / SGMS2 Antibody (aa336-365, APC) - LS-C240705 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMS2 / SGMS2 Antibody (aa336-365, Biotin) - LS-C240706 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMS2 / SGMS2 Antibody (aa336-365, FITC) - LS-C240707 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMS2 / SGMS2 Antibody (C-Terminus, Azide-free, HRP) - LS-C248139 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMS2 / SGMS2 Antibody (aa71-120) - LS-C102514 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SGMS2 antibody LS-C102514 Western blot of 293T cell lysate.

Anti-SMS2 / SGMS2 Antibody (aa336-365, PE) - LS-C240712 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMS2 / SGMS2 Antibody (aa336-365, Azide-free, HRP) - LS-C248141 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMS2 / SGMS2 Antibody (C-Terminus) - LS-C325062 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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