SGMS2

Gene Symbol	SGMS2
Entrez Gene	166929
Alt Symbol	SMS2
Species	Human
Gene Type	protein-coding
Description	sphingomyelin synthase 2
Other Description	SM synthase|phosphatidylcholine:ceramide cholinephosphotransferase 2
Swissprots	B2RA61 A8K2S9 Q8NHU3
Accessions	EAX06211 EAX06212 EAX06213 Q8NHU3 AF452717 AAP13352 AK290344 BAF83033 AK314049 BAG36758 AL833599 BC028705 AAH28705 BC041369 AAH41369 BX649142 DB048409 DC417367 XM_006714121 XP_006714184 XM_011531698 XP_011530000 XM_011531699 XP_011530001 XM_011531700 XP_011530002 XM_011531701 XP_011530003 XM_011531702 XP_011530004 NM_001136257 NP_001129729 NM_001136258 NP_001129730 NM_152621 NP_689834
Function	Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity. {ECO:0000269|PubMed:14685263, ECO:0000269|PubMed:17449912}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly plasma membrane, some in Golgi apparatus. Some localization in the perinuclear region where it colocalizes with a sialyltransferase.
Tissue Specificity	Brain, heart, kidney, liver, muscle and stomach. Also expressed in a number of cell lines such as carcinoma HeLa cells, hepatoma Hep-G2 cells, and colon carcinoma Caco-2 cells. {ECO:0000269|PubMed:14685263}.
Top Pathways	Sphingolipid signaling pathway, Sphingolipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SMS2 CRISPR/Cas9 KO Plasmid (h) - sc-405416 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SMS2 HDR Plasmid (h) - sc-405416-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SMS2 Double Nickase Plasmid (h) - sc-405416-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SMS2 Double Nickase Plasmid (h2) - sc-405416-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SMS2 CRISPR Activation Plasmid (h) - sc-405416-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SMS2 CRISPR Activation Plasmid (h2) - sc-405416-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

SMS2 Lentiviral Activation Particles (h) - sc-405416-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

SMS2 Lentiviral Activation Particles (h2) - sc-405416-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Sphingomyelin Synthase 2 siRNA (h) - sc-44429 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Sphingomyelin Synthase 2 shRNA Plasmid (h) - sc-44429-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Sphingomyelin Synthase 2 shRNA (h) Lentiviral Particles - sc-44429-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Sphingomyelin Synthase 2 RNAi - H00166929-R01V from Novus Biologicals Category siRNA Prices $629.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU076301 from Sigma-Aldrich Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN19232 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19232 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03506 from Sigma-Aldrich Category miRNA

SGMS2 siRNA (Human) - CRJ6051 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Sphingomyelin Synthase 2 RNAi - H00166929-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

SGMS2 - MBS8208952 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human SGMS2 (NM_152621.5) - SHH406312 from Creative biogene Category siRNA Species Reactivities Human

Human SGMS2 siRNA - orb276552 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SGMS2 shRNA Plasmid (Human) - CHJ6051 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SGMS2 miRNA 3'UTR clone - MiUTR4H-TG08009 from Creative biogene Species Reactivities Human

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