TUT1

Gene Symbol	TUT1
Entrez Gene	64852
Alt Symbol	PAPD2, RBM21, STARPAP, TUTase, URLC6
Species	Human
Gene Type	protein-coding
Description	terminal uridylyl transferase 1, U6 snRNA-specific
Other Description	PAP-associated domain-containing 2|RNA binding motif protein 21|RNA uridylyltransferase|RNA-binding motif protein 21|RNA-binding protein 21|TUTase 6|U6 TUTase|U6 snRNA-specific terminal uridylyltransferase 1|U6-TUTase|nuclear speckle targeted phosphatidylinositol 4-phosphate 5-kinase type I-alpha regulated-poly(A) polymerase|nuclear speckle-targeted PIPK1A-regulated-poly(A) polymerase|poly(A) polymerase associated domain containing 2|speckle targeted PIP5K1A-regulated poly(A) polymerase|star-PAP|up-regulated in lung cancer 6
Swissprots	Q7L583 Q9H6E5 Q9H6H7 A1A527 Q2NL65 A8K995
Accessions	EAW74029 Q9H6E5 AB101208 BAQ19752 AK025920 BAB15282 AK026000 BAB15314 AK292610 BAF85299 BC005013 AAH05013 BC110910 AAI10911 BC128263 AAI28264 CA444886 DQ586957 NM_022830 NP_073741
Function	Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication- dependent histone mRNA degradation. {ECO:0000269|PubMed:16790842, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:21102410}.
Subcellular Location	Nucleus, nucleolus. Nucleus speckle.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:18288197}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TUTase (G-20) - sc-162362 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TUTase (N-16) - sc-162364 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-TUT1 antibody - ab86161 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TUT1 antibody - ab110988 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TUT1 antibody - ab86590 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TUT1 antibody - N-terminal - ab139985 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TUT1 Antibody (aa291-340) - LS-C120440 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TUT1 Antibody (aa829-878) - LS-C101778 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TUT1 Antibody (N-Terminus) - LS-C169546 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TUT1 Antibody (aa253-302) - LS-C101437 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

TUT1 Antibody - NBP1-56254 from Novus Biologicals Prices $229.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TUT1 antibody produced in rabbit - SAB2102610 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TUT1 antibody produced in rabbit - SAB2103091 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-TUT1 antibody produced in rabbit - SAB4300788 from Sigma-Aldrich Prices $230.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

TUT1 antibody - N-terminal region (ARP33292_P050) - ARP33292_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

TUT1 antibody - middle region (ARP39567_P050) - ARP39567_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

TUT1 Antibody (OAAF04400) - OAAF04400 from Aviva Systems Biology Prices $289.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

TUT1 antibody - 70R-7980 from Fitzgerald Prices $345.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

TUT1 antibody - 70R-8371 from Fitzgerald Prices $345.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

TUT1 Antibody - abx014970 from Abbexa Host Rabbit Clonality Polyclonal

TUT1 Antibody - 25-128 from ProSci Prices $315.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

TUT1 Antibody - 25-532 from ProSci Prices $315.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TUTase antibody - STJ96149 from St John's Laboratory Ltd Host Rabbit Clonality Polyclonal

TUT1 Polyclonal Antibody - PA003593-C19350 from Syd Labs Prices $150.00, $250.00 Sizes 50 µg, 100 µg Host Rabbit Clonality Polyclonal

TUT1 Antibody - 35114 from Signalway Antibody Prices $189.00, $279.00 Sizes 50 µl, 100 µl Host Rabbit Clonality Polyclonal

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