| Gene Symbol |
TUT1
|
| Entrez Gene |
64852
|
| Alt Symbol |
PAPD2, RBM21, STARPAP, TUTase, URLC6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
terminal uridylyl transferase 1, U6 snRNA-specific
|
| Other Description |
PAP-associated domain-containing 2|RNA binding motif protein 21|RNA uridylyltransferase|RNA-binding motif protein 21|RNA-binding protein 21|TUTase 6|U6 TUTase|U6 snRNA-specific terminal uridylyltransferase 1|U6-TUTase|nuclear speckle targeted phosphatidylinositol 4-phosphate 5-kinase type I-alpha regulated-poly(A) polymerase|nuclear speckle-targeted PIPK1A-regulated-poly(A) polymerase|poly(A) polymerase associated domain containing 2|speckle targeted PIP5K1A-regulated poly(A) polymerase|star-PAP|up-regulated in lung cancer 6
|
| Swissprots |
Q7L583 Q9H6E5 Q9H6H7 A1A527 Q2NL65 A8K995
|
| Accessions |
EAW74029 Q9H6E5 AB101208 BAQ19752 AK025920 BAB15282 AK026000 BAB15314 AK292610 BAF85299 BC005013 AAH05013 BC110910 AAI10911 BC128263 AAI28264 CA444886 DQ586957 NM_022830 NP_073741
|
| Function |
Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication- dependent histone mRNA degradation. {ECO:0000269|PubMed:16790842, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:21102410}.
|
| Subcellular Location |
Nucleus, nucleolus. Nucleus speckle.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:18288197}.
|