MARK3

Gene Symbol MARK3
Entrez Gene 4140
Alt Symbol CTAK1, KP78, PAR1A, Par-1a
Species Human
Gene Type protein-coding
Description MAP/microtubule affinity-regulating kinase 3
Other Description C-TAK1|ELKL motif kinase 2|EMK-2|cdc25C-associated protein kinase 1|protein kinase STK10|ser/Thr protein kinase PAR-1|serine/threonine-protein kinase p78
Swissprots Q9UN34 Q9UMY9 Q8TB41 Q96RG1 Q8WX83 P27448 O60219 Q86TT8
Accessions EAW81812 EAW81813 EAW81814 EAW81815 EAW81816 EAW81817 EAW81818 EAW81819 P27448 AB209542 BAD92779 AF170723 AAD51631 AF387637 AAK82367 AF465413 AAL69982 AK055814 AK124459 AK296643 BAG59243 AK307448 BC024773 AAH24773 BX161395 CAD61882 BX248250 CAD62578 DA707357 DQ368336 ABD15137 DQ891715 ABM82641 DQ894892 ABM85818 M80359 AAA59991 M83780 U64205 AAC15093 XM_005267641 XP_005267698 XM_005267642 XP_005267699 XM_005267643 XP_005267700 XM_006720146 XP_006720209 XM_011536768 XP_011535070 XM_011536769 XP_011535071 XM_011536770 XP_011535072 XM_011536771 XP_011535073 NM_001128918 NP_001122390 NM_001128919 NP_001122391 NM_001128920 NP_001122392 NM_001128921 NP_001122393 NM_002376 NP_002367
Function Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. {ECO:0000269|PubMed:16980613}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:21145462}.
Tissue Specificity Ubiquitous.

MARK3 Antibody - 9311 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using MARK3 Antibody.

MARK3 (F-6) - sc-376116 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MARK3 (F-6): sc-376116. Western blot analysis of MARK3 expression in non-transfected: sc-117752 (A) and human MARK3 transfected: sc-114018 (B) 293T whole cell lysates.

MARK3 (G-11) - sc-365461 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MARK3 (G-11): sc-365461. Western blot analysis of MARK3 expression in non-transfected: sc-117752 (A) and human MARK3 transfected: sc-114018 (B) 293T whole cell lysates.

MARK3 (C-16) - sc-5698 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MARK3 (G-7) - sc-376115 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MARK3 (G-7): sc-376115. Western blot analysis of MARK3 expression in non-transfected: sc-117752 (A) and human MARK3 transfected: sc-114018 (B) 293T whole cell lysates.

MARK3 (H-55) - sc-50342 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MARK3 (H-55): sc-50342. Western blot analysis of MARK3 expression in non-transfected: sc-117752 (A) and human MARK3 transfected: sc-114018 (B) 293T whole cell lysates.

MARK3 (N-16) - sc-5695 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MARK3 (N-16): sc-5695. Western blot analysis of MARK3 expression in non-transfected: sc-117752 (A) and human MARK3 transfected: sc-114018 (B) 293T whole cell lysates.

Anti-Mark3 antibody - ab77199 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing HeLa cells stained with ab77199 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab77199, 0.01μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2b [PLPV219] (ab91366, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HeLa cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Mark3 antibody - ab117558 from Abcam

Prices $407.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
ab117558, at 10 µg/ml, staining Mark3 in formalin fixed, paraffin embedded Human small intestine tissue by Immunohistochemistry.

Anti-Mark3 antibody - ab133708 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human small intestine tissue labelling Mark3 with ab133708 at 10 µg/ml, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Mark3 antibody - ab79577 from Abcam

Prices $370.00
Sizes 125 µg
Host Sheep
Clonality Polyclonal
All lanes : Anti-Mark3 antibody (ab79577) at 5 µg/mlLane 1 : Recombinant His-tagged Mark3Lane 2 : RKO cell lysateLane 3 : HCT116 cell lysate

Anti-Mark3 antibody - ab94499 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Mark3 antibody (ab94499) at 1 µg/ml (in 5% skim milk / PBS buffer) + 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Mark3 antibody - ab126223 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Mark3 antibody (ab126223) at 1/2000 dilution + HCT116 whole cell lysate at 30 µg

Anti-Mark3 antibody [EPR633Y] - ab52626 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR633Y
Overlay histogram showing HeLa cells stained with ab52626 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab52626, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-Mark3 antibody - C-terminal - ab172864 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Mark3 antibody - C-terminal (ab172864) at 1/500 dilution + Mouse cerebellum tissue lysates at 35 µg

Anti-C-TAK1 / MARK3 Antibody - LS-C310947 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-C-TAK1 / MARK3 Antibody (aa8-57) - LS-C292167 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-C-TAK1 / MARK3 Antibody (aa608-636) - LS-C164479 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Mark3 Antibody western blot of mouse cerebellum tissue lysates (35 ug/lane). The Mark3 antibody detected the Mark3 protein (arrow).

Anti-C-TAK1 / MARK3 Antibody (aa607-636) - LS-C322863 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-C-TAK1 / MARK3 Antibody (clone 2G12) - LS-C169131 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G12
IHC of paraffin-embedded bladder cancer tissues using MARK3 mouse monoclonal antibody with DAB staining.

Anti-C-TAK1 / MARK3 Antibody (clone 1A10) - LS-C197651 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A10
Western Blot analysis of MARK3 expression in transfected 293T cell line by MARK3 monoclonal antibody (M01), clone 1A10.Lane 1: MARK3 transfected lysate(81.4 KDa).Lane 2: Non-transfected lysate.

Anti-C-TAK1 / MARK3 Antibody (aa473-729, clone 2A4) - LS-C339710 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MARK3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MARK3.

Anti-C-TAK1 / MARK3 Antibody (aa473-729, clone 3E11) - LS-C339751 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3E11
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MARK3 mouse monoclonal antibody. (heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-C-TAK1 / MARK3 Antibody (aa473-729, clone 2D3) - LS-C339714 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MARK3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MARK3.

Anti-C-TAK1 / MARK3 Antibody (aa473-729, clone 5E5) - LS-C339779 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5E5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MARK3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MARK3.
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