PPP1R9B

Gene Symbol PPP1R9B
Entrez Gene 84687
Alt Symbol PPP1R6, PPP1R9, SPINO, Spn
Species Human
Gene Type protein-coding
Description protein phosphatase 1, regulatory subunit 9B
Other Description neurabin-2|neurabin-II|protein phosphatase 1, regulatory (inhibitor) subunit 9B|protein phosphatase 1, regulatory subunit 9B, spinophilin
Swissprots Q96SB3 Q8TCR9
Accessions EAW94636 EAW94637 EAW94638 Q96SB3 AI056581 AJ401189 CAC37685 AK054907 BAG51442 AL157449 AL713642 CAD28455 BC008564 AAH08564 BC011232 BC016162 AAH16162 BF109903 BF448737 BM991997 CB052174 XM_011525380 XP_011523682 XM_011525381 XP_011523683 XR_934576 NM_032595 NP_115984
Function Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha- adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse. Cell junction, adherens junction {ECO:0000250}. Cytoplasm. Cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle membrane. Note=Enriched at synapse and cadherin-based cell- cell adhesion sites. In neurons, both cytosolic and membrane- associated, and highly enriched in the postsynaptic density apposed to exitatory synapses. Colocalizes with PPP1R2 at actin- rich adherens junctions in epithelial cells and in dendritic spines (By similarity). Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. {ECO:0000250}.

Spinophilin (E1E7R) Rabbit mAb - 14136 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone E1E7R
Western blot analysis of extracts from various tissues and cell lines using Spinophilin (E1E7R) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Spinophilin Antibody - 9061 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Neurabin-II (D-7) - sc-373974 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Neurabin-II (D-7): sc-373974. Western blot analysis of Neurabin-II expression in IMR-32 whole cell lysate.

Neurabin-II (H-170) - sc-32933 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Neurabin-II (H-170): sc-32933. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic staining.

Anti-Spinophilin/Neurabin 2 antibody - ab18561 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Spinophilin/Neurabin 2 antibody - ab50184 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Spinophilin/Neurabin 2 antibody - ab203275 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat brain tissue labeling Spinophilin/Neurabin 2 with ab203275 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Anti-Spinophilin/Neurabin 2 antibody - ab129706 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Spinophilin/Neurabin 2 antibody (ab129706) at 1/100 dilution + Ramos cell line lysate at 35 µg

Anti-PPP1R9B / Spinophilin Antibody (aa286-390) - LS-C39221 from LifeSpan Bioscience

Prices $605.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-PPP1R9B / Spinophilin Antibody (aa23-53, AP) - LS-C216921 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1R9B / Spinophilin Antibody (aa23-53, APC) - LS-C216922 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1R9B / Spinophilin Antibody (aa289-412) - LS-C184894 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-PPP1R9B / Spinophilin Antibody (aa23-53, FITC) - LS-C216924 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1R9B / Spinophilin Antibody (aa23-53, Biotin) - LS-C216923 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1R9B / Spinophilin Antibody (aa23-53, Azide-free, HRP) - LS-C216925 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1R9B / Spinophilin Antibody (aa23-53) - LS-C330000 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1R9B / Spinophilin Antibody (aa23-53, PE) - LS-C216926 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP1R9B / Spinophilin Antibody (aa24-53) - LS-C162085 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PPP1R9B Antibody western blot of Ramos cell line lysates (35 ug/lane). The PPP1R9B antibody detected the PPP1R9B protein (arrow).

Anti-PPP1R9B / Spinophilin Antibody - LS-C332719 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using PPP1R9B antibody.

PPP1R9B/Spinophilin Antibody - AF6465 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal
Western Blot PPP1R9B/Spinophilin Antibody

PPP1R9B/Spinophilin Antibody - H00084687-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Spinophilin/Neurabin 2 Antibody - bs-12146R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Formalin-fixed and paraffin embedded rat brain labeled with Anti-Spinophilin/Neurabin 2 Polyclonal Antibody, Unconjugated (bs-12146R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Spinophilin/Neurabin 2 Antibody, ALEXA FLUOR® 350 Conjugated - bs-12146R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit

Spinophilin/Neurabin 2 Antibody, ALEXA FLUOR® 488 Conjugated - bs-12146R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit

Spinophilin/Neurabin 2 Antibody, ALEXA FLUOR® 555 Conjugated - bs-12146R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
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