| Gene Symbol |
PPP1R9B
|
| Entrez Gene |
84687
|
| Alt Symbol |
PPP1R6, PPP1R9, SPINO, Spn
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 1, regulatory subunit 9B
|
| Other Description |
neurabin-2|neurabin-II|protein phosphatase 1, regulatory (inhibitor) subunit 9B|protein phosphatase 1, regulatory subunit 9B, spinophilin
|
| Swissprots |
Q96SB3 Q8TCR9
|
| Accessions |
EAW94636 EAW94637 EAW94638 Q96SB3 AI056581 AJ401189 CAC37685 AK054907 BAG51442 AL157449 AL713642 CAD28455 BC008564 AAH08564 BC011232 BC016162 AAH16162 BF109903 BF448737 BM991997 CB052174 XM_011525380 XP_011523682 XM_011525381 XP_011523683 XR_934576 NM_032595 NP_115984
|
| Function |
Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha- adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse. Cell junction, adherens junction {ECO:0000250}. Cytoplasm. Cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle membrane. Note=Enriched at synapse and cadherin-based cell- cell adhesion sites. In neurons, both cytosolic and membrane- associated, and highly enriched in the postsynaptic density apposed to exitatory synapses. Colocalizes with PPP1R2 at actin- rich adherens junctions in epithelial cells and in dendritic spines (By similarity). Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. {ECO:0000250}.
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