PPP1R9B

Gene Symbol	PPP1R9B
Entrez Gene	84687
Alt Symbol	PPP1R6, PPP1R9, SPINO, Spn
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 1, regulatory subunit 9B
Other Description	neurabin-2|neurabin-II|protein phosphatase 1, regulatory (inhibitor) subunit 9B|protein phosphatase 1, regulatory subunit 9B, spinophilin
Swissprots	Q96SB3 Q8TCR9
Accessions	EAW94636 EAW94637 EAW94638 Q96SB3 AI056581 AJ401189 CAC37685 AK054907 BAG51442 AL157449 AL713642 CAD28455 BC008564 AAH08564 BC011232 BC016162 AAH16162 BF109903 BF448737 BM991997 CB052174 XM_011525380 XP_011523682 XM_011525381 XP_011523683 XR_934576 NM_032595 NP_115984
Function	Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha- adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse. Cell junction, adherens junction {ECO:0000250}. Cytoplasm. Cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle membrane. Note=Enriched at synapse and cadherin-based cell- cell adhesion sites. In neurons, both cytosolic and membrane- associated, and highly enriched in the postsynaptic density apposed to exitatory synapses. Colocalizes with PPP1R2 at actin- rich adherens junctions in epithelial cells and in dendritic spines (By similarity). Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PPP1R9B / Spinophilin ELISA Kit (Sandwich ELISA) - LS-F12132 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Neurabin-2, PPP1R9B, Human, ELISA Kit - E8951h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.156-10 ng/mL

protein phosphatase 1, regulatory (inhibitor) subunit 9B, ELISA Kit - MBS927852 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 11.72 pg/ml Range 46.88 pg/ml -3000 pg/ml

Human Neurabin-2(PPP1R9B) ELISA kit - CSB-EL018558HU from Cusabio Category ELISA Kit Sensitivity 11.72 pg/ml Range 46.88 pg/ml-3000 pg/ml

Rat PPP1R9B / Spinophilin ELISA Kit (Sandwich ELISA) - LS-F20255 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Mouse PPP1R9B / Spinophilin ELISA Kit (Custom ELISA) - LS-F20256 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human Neurabin-2 ELISA Kit - abx251776 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human Neurabin-2 (PPP1R9B) ELISA Kit - EKC34764 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 11.72 pg/ml Range 46.88 pg/ml-3000 pg/ml

Human Neurabin-2 ELISA Kit - EKE55439 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.098 ng/mL Range 0.156-10 ng/mL

PPP1R9B - EKH4826 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

PPP1R9B ELISA Kit (Human) (OKEH01882) - OKEH01882 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.098 ng/mL Range 0.156 - 10 ng/mL

Human PPP1R9B ELISA Kit - E031733 from Biobool Category ELISA Kit Sensitivity 11.72 pg/ml

Human Neurabin-2 ELISA Kit - EK4861 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Range 0.156-10 ng/ml

Neurabin-2, ELISA Kit - MBS2887462 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/mL

Neurabin-2, ELISA Kit - MBS9428687 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Sensitivity Less than 0.098ng/mL Range 0.156-10 ng/mL

Neurabin-2, ELISA Kit - MBS762621 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Human PPP1R9B / Spinophilin ELISA Kit (Sandwich ELISA) - LS-F35958 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.094 Range 0.156-10 ng/ml

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