Gene Symbol |
CFI
|
Entrez Gene |
3426
|
Alt Symbol |
AHUS3, ARMD13, C3BINA, C3b-INA, FI, IF, KAF
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
complement factor I
|
Other Description |
C3B/C4B inactivator|C3b-inactivator|Konglutinogen-activating factor|complement component I|complement control protein factor I|complement factor I heavy chain|light chain of factor I
|
Swissprots |
P05156 O60442
|
Accessions |
AAC08733 EAX06250 EAX06251 EAX06252 P05156 AK122686 AK290625 BAF83314 AK299232 BAG61264 BC005275 BC020718 AAH20718 BM955734 BP235907 DC392360 J02770 AAA52455 N63668 Y00318 CAA68416 XM_005262975 XP_005263032 XM_005262976 XP_005263033 XM_006714209 XP_006714272 XM_006714210 XP_006714273 XM_011531920 XP_011530222 NM_000204 NP_000195
|
Function |
Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.
|
Subcellular Location |
Secreted, extracellular space.
|
Tissue Specificity |
Plasma.
|
Top Pathways |
Complement and coagulation cascades, Staphylococcus aureus infection
|