Gene Symbol | CFI |
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Entrez Gene | 3426 |
Alt Symbol | AHUS3, ARMD13, C3BINA, C3b-INA, FI, IF, KAF |
Species | Human |
Gene Type | protein-coding |
Description | complement factor I |
Other Description | C3B/C4B inactivator|C3b-inactivator|Konglutinogen-activating factor|complement component I|complement control protein factor I|complement factor I heavy chain|light chain of factor I |
Swissprots | P05156 O60442 |
Accessions | AAC08733 EAX06250 EAX06251 EAX06252 P05156 AK122686 AK290625 BAF83314 AK299232 BAG61264 BC005275 BC020718 AAH20718 BM955734 BP235907 DC392360 J02770 AAA52455 N63668 Y00318 CAA68416 XM_005262975 XP_005263032 XM_005262976 XP_005263033 XM_006714209 XP_006714272 XM_006714210 XP_006714273 XM_011531920 XP_011530222 NM_000204 NP_000195 |
Function | Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. |
Subcellular Location | Secreted, extracellular space. |
Tissue Specificity | Plasma. |
Top Pathways | Complement and coagulation cascades, Staphylococcus aureus infection |
Factor I CRISPR/Cas9 KO Plasmid (h) - sc-407715 from Santa Cruz Biotechnology
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Factor I HDR Plasmid (h) - sc-407715-HDR from Santa Cruz Biotechnology
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Factor I Double Nickase Plasmid (h) - sc-407715-NIC from Santa Cruz Biotechnology
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Factor I Double Nickase Plasmid (h2) - sc-407715-NIC-2 from Santa Cruz Biotechnology
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Factor I CRISPR Activation Plasmid (h) - sc-407715-ACT from Santa Cruz Biotechnology
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Factor I CRISPR Activation Plasmid (h2) - sc-407715-ACT-2 from Santa Cruz Biotechnology
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Factor I Lentiviral Activation Particles (h) - sc-407715-LAC from Santa Cruz Biotechnology
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Factor I Lentiviral Activation Particles (h2) - sc-407715-LAC-2 from Santa Cruz Biotechnology
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Factor I siRNA (h) - sc-72081 from Santa Cruz Biotechnology
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Factor I shRNA Plasmid (h) - sc-72081-SH from Santa Cruz Biotechnology
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Factor I shRNA (h) Lentiviral Particles - sc-72081-V from Santa Cruz Biotechnology
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Complement Factor I RNAi - H00003426-R02 from Novus Biologicals
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MISSION® esiRNA - EHU104231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6005 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6005 from Sigma-Aldrich
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CFI siRNA (Human) - CRH2320 from Cohesion Biosciences
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CFI - MBS8239291 from MyBioSource
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shRNA set against Human CFI (NM_000204.3) - SHH262465 from Creative biogene
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shRNA set against Human CFI(NM_000204.3) - SHG169479 from Creative biogene
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Human CFI siRNA - orb262822 from Biorbyt
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CFI shRNA Plasmid (Human) - CHH2320 from Cohesion Biosciences
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CFI miRNA 3'UTR clone - MiUTR1H-02076 from Creative biogene
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