| Gene Symbol |
NFKB2
|
| Entrez Gene |
4791
|
| Alt Symbol |
CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p52
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
|
| Other Description |
DNA-binding factor KBF2|NFKB, p52/p100 subunit|lymphocyte translocation chromosome 10 protein|nuclear factor Kappa-B, subunit 2|nuclear factor NF-kappa-B p100 subunit|nuclear factor NF-kappa-B p52 subunit|nuclear factor of Kappa light chain gene enhancer in B cells 2|oncogene Lyt-10|transcription factor NFKB2
|
| Swissprots |
Q04860 D3DR83 Q00653 Q9H471 A8K9D9 Q9H472 Q9BU75
|
| Accessions |
AAA68171 AAB23437 AAW56071 CAA58721 CBX47422 CBX47423 CBX47424 EAW49700 EAW49701 EAW49702 EAW49703 EAW49704 EAW49705 EAW49706 Q00653 AK098415 AK292654 BAF85343 BC002844 AAH02844 BT009769 AAP88771 BY799958 DA349980 DA408461 DA711063 DB091090 S76638 AAB21124 U09609 AAA21462 X61498 CAA43715 X61499 CAA43716 XM_005269860 XP_005269917 XM_005269861 XP_005269918 XM_011539830 XP_011538132 XM_011539831 XP_011538133 NM_001077494 NP_001070962 NM_001261403 NP_001248332 NM_001288724 NP_001275653 NM_002502 NP_002493
|
| Function |
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cy
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
|
| Top Pathways |
MAPK signaling pathway, Osteoclast differentiation, HTLV-I infection, Legionellosis, Viral carcinogenesis
|