NFKB2

Gene Symbol	NFKB2
Entrez Gene	4791
Alt Symbol	CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p52
Species	Human
Gene Type	protein-coding
Description	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Other Description	DNA-binding factor KBF2|NFKB, p52/p100 subunit|lymphocyte translocation chromosome 10 protein|nuclear factor Kappa-B, subunit 2|nuclear factor NF-kappa-B p100 subunit|nuclear factor NF-kappa-B p52 subunit|nuclear factor of Kappa light chain gene enhancer in B cells 2|oncogene Lyt-10|transcription factor NFKB2
Swissprots	Q04860 D3DR83 Q00653 Q9H471 A8K9D9 Q9H472 Q9BU75
Accessions	AAA68171 AAB23437 AAW56071 CAA58721 CBX47422 CBX47423 CBX47424 EAW49700 EAW49701 EAW49702 EAW49703 EAW49704 EAW49705 EAW49706 Q00653 AK098415 AK292654 BAF85343 BC002844 AAH02844 BT009769 AAP88771 BY799958 DA349980 DA408461 DA711063 DB091090 S76638 AAB21124 U09609 AAA21462 X61498 CAA43715 X61499 CAA43716 XM_005269860 XP_005269917 XM_005269861 XP_005269918 XM_011539830 XP_011538132 XM_011539831 XP_011538133 NM_001077494 NP_001070962 NM_001261403 NP_001248332 NM_001288724 NP_001275653 NM_002502 NP_002493
Function	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cy
Subcellular Location	Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Top Pathways	MAPK signaling pathway, Osteoclast differentiation, HTLV-I infection, Legionellosis, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phospho-NF-κB2 p100 (Ser866/870) Antibody - 4810 from Cell Signaling Technology Prices $109.00, $287.00, $678.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots) Host Rabbit Clonality Polyclonal

NF-κB2 p100/p52 Antibody - 4882 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

NF-κB2 p100/p52 (18D10) Rabbit mAb - 3017 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone 18D10

Phospho-NF-KappaB2 p100 (Ser864) Antibody - 4881 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

NFκB p52 (C-5) - sc-7386 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

NFκB p52 (K-27) - sc-298 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

NFκB p52 (447) - sc-848 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

p-NFκB p100 (Ser 866) - sc-101742 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

p-NFκB p100 (Ser 870) - sc-101743 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-NFkB p100 / p52 (phospho S865) antibody - ab31474 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFkB p100 / p52 (phospho S866) antibody - ab194919 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NFkB p100 / p52 (phospho S870) antibody - ab194924 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NFkB p100 / p52 (phospho S872) antibody - ab63549 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFkB p100 / p52 antibody - ab86090 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFkB p100 / p52 antibody - ab6549 from Abcam Prices $372.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NFkB p100 / p52 antibody [0.T.173] - ab32859 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 0.T.173

Anti-NFkB p100 / p52 antibody [9D2] - ab71108 from Abcam Prices $378.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 9D2

Anti-NFkB p100 / p52 antibody [EPR4686] - ab109440 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4686

Anti-NFkB p100 / p52 antibody [EPR4686-66] - ab175192 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4686-66

Anti-NFkB p100 / p52 antibody - ChIP Grade - ab7972 from Abcam Prices $385.00 Sizes 1 ml Host Rabbit Clonality Polyclonal

Anti-NFkB p100 (phospho S869) antibody - ab31475 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFkB p100 antibody - ab31432 from Abcam Prices $379.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFkB p100 antibody - ab131539 from Abcam Prices $384.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFKB2 Antibody (aa1-340) - LS-C344010 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFKB2 Antibody (aa5-21) - LS-C313084 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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