PDE3B

Gene Symbol PDE3B
Entrez Gene 5140
Alt Symbol HcGIP1, cGIPDE1
Species Human
Gene Type protein-coding
Description phosphodiesterase 3B, cGMP-inhibited
Other Description CGI-PDE B|CGIP1|cGMP-inhibited 3',5'-cyclic phosphodiesterase B|cyclic GMP-inhibited phosphodiesterase B|cyclic nucleotide phosphodiesterase
Swissprots O00639 Q6SEI4 Q13370 B7ZM37 Q14408
Accessions AAC50724 BAA09306 CAA64776 EAW68474 EAW68475 Q13370 AB209326 BAD92563 AY459346 AAR24292 BC136565 AAI36566 BC136566 AAI36567 BC144248 AAI44249 BC146828 AAI46829 BC150307 AAI50308 BC150322 AAI50323 X95520 CAA64774 XM_006718249 XP_006718312 XM_011520183 XP_011518485 NM_000922 NP_000913
Function Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. {ECO:0000269|PubMed:15147193, ECO:0000269|PubMed:21393242}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Abundant in adipose tissues.
Top Pathways Insulin signaling pathway, Progesterone-mediated oocyte maturation, Morphine addiction, cGMP-PKG signaling pathway, cAMP signaling pathway

Human PDE3B ORF clone (NM_000922.3) - CDCL147369 from Creative biogene

Species Human
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