| Gene Symbol |
PDE3B
|
| Entrez Gene |
5140
|
| Alt Symbol |
HcGIP1, cGIPDE1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphodiesterase 3B, cGMP-inhibited
|
| Other Description |
CGI-PDE B|CGIP1|cGMP-inhibited 3',5'-cyclic phosphodiesterase B|cyclic GMP-inhibited phosphodiesterase B|cyclic nucleotide phosphodiesterase
|
| Swissprots |
O00639 Q6SEI4 Q13370 B7ZM37 Q14408
|
| Accessions |
AAC50724 BAA09306 CAA64776 EAW68474 EAW68475 Q13370 AB209326 BAD92563 AY459346 AAR24292 BC136565 AAI36566 BC136566 AAI36567 BC144248 AAI44249 BC146828 AAI46829 BC150307 AAI50308 BC150322 AAI50323 X95520 CAA64774 XM_006718249 XP_006718312 XM_011520183 XP_011518485 NM_000922 NP_000913
|
| Function |
Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. {ECO:0000269|PubMed:15147193, ECO:0000269|PubMed:21393242}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Abundant in adipose tissues.
|
| Top Pathways |
Insulin signaling pathway, Progesterone-mediated oocyte maturation, Morphine addiction, cGMP-PKG signaling pathway, cAMP signaling pathway
|