PDE3B

Gene Symbol PDE3B
Entrez Gene 5140
Alt Symbol HcGIP1, cGIPDE1
Species Human
Gene Type protein-coding
Description phosphodiesterase 3B, cGMP-inhibited
Other Description CGI-PDE B|CGIP1|cGMP-inhibited 3',5'-cyclic phosphodiesterase B|cyclic GMP-inhibited phosphodiesterase B|cyclic nucleotide phosphodiesterase
Swissprots O00639 Q6SEI4 Q13370 B7ZM37 Q14408
Accessions AAC50724 BAA09306 CAA64776 EAW68474 EAW68475 Q13370 AB209326 BAD92563 AY459346 AAR24292 BC136565 AAI36566 BC136566 AAI36567 BC144248 AAI44249 BC146828 AAI46829 BC150307 AAI50308 BC150322 AAI50323 X95520 CAA64774 XM_006718249 XP_006718312 XM_011520183 XP_011518485 NM_000922 NP_000913
Function Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. {ECO:0000269|PubMed:15147193, ECO:0000269|PubMed:21393242}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Abundant in adipose tissues.
Top Pathways Insulin signaling pathway, Progesterone-mediated oocyte maturation, Morphine addiction, cGMP-PKG signaling pathway, cAMP signaling pathway

PDE3B (C-20) - sc-11838 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDE3B (C-20): sc-11838. Western blot analysis of PDE3B expression in Jurkat (A) and K-562 (B) whole cell lysates.

PDE3B (D-17) - sc-11837 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PDE3B (F-9) - sc-376823 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDE3B (F-9): sc-376823. Western blot analysis of PDE3B expression in Jurkat whole cell lysate.

PDE3B (H-300) - sc-20793 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PDE3B (H-300): sc-20793. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

PDE3B (N-20) - sc-11835 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDE3B (N-20): sc-11835. Western blot analysis of PDE3B expression in Jurkat whole cell lysate.

Anti-PDE3B antibody - ab42091 from Abcam

Prices $370.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-PDE3B antibody (ab42091) at 1/250 dilution + PDE3B protein

Anti-PDE3B antibody - ab125675 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-PDE3B antibody (ab125675) at 1/2000 dilutionLane 1 : COS cells, non- transfectedLane 2 : COS cells, transfected with Human PDE1A3Lane 3 : COS cells, transfected with Human PDE2A3Lane 4 : COS cells, transfected with Human PDE3ALane 5 : COS cells, transfected with Human PDE3BLane 6 : COS cells, transfected with Human PDE4D2Lane 7 : COS cells, transfected with Human PDE5A1Lane 8 : COS cells, transfected with Human PDE5A3Lane 9 : COS cells, transfected with Human PDE7A1Lane 10 : COS cells, transfected with Human PDE8A1Lane 11 : COS cells, transfected with Human PDE10A1Lane 12 : COS cells, transfected with Human PDE11A1developed using the ECL technique

Anti-PDE3B antibody - ab99289 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PDE3B antibody (ab99289) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgdeveloped using the ECL technique

Anti-PDE3B antibody - ab99290 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PDE3B antibody (ab99290) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µg

Anti-PDE3B antibody - ab55558 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55558 PDE3B antibody at 1ug/ml.

Anti-PDE3B Antibody - LS-C147068 from LifeSpan Bioscience

Prices $410.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE3B Antibody (clone SMCP3B) - LS-C106883 from LifeSpan Bioscience

Prices $255.00, $375.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone SMCP3B
Lysates prepared from mouse heart (lane 1) or lymph node cells (lane 2) were run under reducing conditions on a 3-8% Tris-Acetate gel. The membrane was probed with 2 ug/mL anti-mouse PDE3B (SMCP3B), followed by HRP-conjugated anti-rat IgG.

Anti-PDE3B Antibody (aa400-427, AP) - LS-C265875 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE3B Antibody (aa400-427, Biotin) - LS-C265876 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE3B Antibody (aa400-427, APC) - LS-C265877 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE3B Antibody (aa400-427, FITC) - LS-C265878 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE3B Antibody (aa400-427, Azide-free, HRP) - LS-C265879 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE3B Antibody (aa400-427, PE) - LS-C265880 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE3B Antibody (aa500-550) - LS-C286136 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE3B Antibody (aa1062-1112) - LS-C286138 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE3B Antibody (aa407-435) - LS-C323886 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE3B Antibody (aa864-913) - LS-C110938 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PDE3B antibody LS-C110938 Western blot of 293T cell lysate.

Anti-PDE3B Antibody (clone 4A4) - LS-C197859 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A4
Detection limit for recombinant GST tagged PDE3B is approximately 0.03 ng/ml as a capture antibody.

Anti-PDE3B Antibody (aa400-427) - LS-C163469 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Confocal immunofluorescent of PDE3B Antibody with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

PDE3B Antibody - NBP1-46184 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PDE3B Antibody [NBP1-46184] - Detection of Human PDE3B by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and50 mcg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-PDE3B antibody NBP1-46184 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. PDE3B was also immunoprecipitated by rabbit anti-PDE3B antibody NBP1-46183, which recognizes an upstream epitope. For blotting immunoprecipitated PDE3B, the blot Reagents and Procedures were used. Detection: Chemiluminescence with exposure times of 30 seconds(A) and 10 seconds (B).
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