PDE3B

Gene Symbol	PDE3B
Entrez Gene	5140
Alt Symbol	HcGIP1, cGIPDE1
Species	Human
Gene Type	protein-coding
Description	phosphodiesterase 3B, cGMP-inhibited
Other Description	CGI-PDE B|CGIP1|cGMP-inhibited 3',5'-cyclic phosphodiesterase B|cyclic GMP-inhibited phosphodiesterase B|cyclic nucleotide phosphodiesterase
Swissprots	O00639 Q6SEI4 Q13370 B7ZM37 Q14408
Accessions	AAC50724 BAA09306 CAA64776 EAW68474 EAW68475 Q13370 AB209326 BAD92563 AY459346 AAR24292 BC136565 AAI36566 BC136566 AAI36567 BC144248 AAI44249 BC146828 AAI46829 BC150307 AAI50308 BC150322 AAI50323 X95520 CAA64774 XM_006718249 XP_006718312 XM_011520183 XP_011518485 NM_000922 NP_000913
Function	Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. {ECO:0000269|PubMed:15147193, ECO:0000269|PubMed:21393242}.
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity	Abundant in adipose tissues.
Top Pathways	Insulin signaling pathway, Progesterone-mediated oocyte maturation, Morphine addiction, cGMP-PKG signaling pathway, cAMP signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PDE3B protein fragment - ab125784 from Abcam Category Protein Prices $302.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human PDE3B protein fragment - ab79658 from Abcam Category Protein Prices $492.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human PDE3B protein fragment - ab152597 from Abcam Category Protein Source Wheat germ Species Human

PDE3B Antibody Blocking Peptide - LS-E1366 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDE3B Antibody Blocking Peptide - LS-E16291 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PDE3B Protein - H00005140-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PDE3B-Antibody-Center-Blocking-peptide - BP12018c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDE3B Blocking Peptide - 33R-11027 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

PDE3B Blocking Peptide - 33R-8765 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PDE3B - H00005140-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PDE3B - H00005140-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PDE3B Control Peptide - AP10209CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

PDE3B Control Peptide - AP10211CP-N from Acris Antibodies Category Peptide Prices $255.00 Sizes 100 µg

PDE3B fusion protein - ag18064 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PDE3B fusion protein - Ag19190 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PDE3B, Active Human Recombinant Protein - GWB-495C2E from Genway Biotech Category Protein Prices $600.00 Sizes 10 µg Species Human

Recombinant Human PDE3B, GST-tagged, Active - PDE3B-474H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human PDE3B - PDE3B-29932TH from Creative Biomart Category Protein

Recombinant Human PDE3B (Active), GST-tagged - PDE3B-1526H from Creative Biomart Category Protein Source Sf9 Cells Species Human

Phosphodiesterase 3B, His•Tag ® , Human, Recombinant, S. frugiperda - 524734 from EMD Millipore Species Human

PDE3B Blocking Peptide - 3956BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

PDE3B Protein - abx163328 from Abbexa Category Protein Species Human, Mouse

PDE3B - TP319619 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PDE3B, Recombinant Protein - MBS635538 from MyBioSource Category Protein Prices $715.00 Sizes 10 µg

PDE3B, Peptide - MBS843957 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

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