Gene Symbol | PCGF3 |
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Entrez Gene | 10336 |
Alt Symbol | DONG1, RNF3, RNF3A |
Species | Human |
Gene Type | protein-coding |
Description | polycomb group ring finger 3 |
Other Description | RING finger protein 3A|polycomb group RING finger protein 3|ring finger protein 3 |
Swissprots | Q3KNV8 O15262 D3DVN1 |
Accessions | EAW82651 EAW82652 EAW82653 EAW82654 EAW82655 EAW82656 Q3KNV8 AA401257 AK057124 BAG51868 AK125801 BAG54250 AK225892 AK300290 BAG62047 AL832536 CAD38631 AU132917 BC028026 BC050044 BC061897 BC107061 AAI07062 BI758022 BQ882065 BX640894 BX648409 CA454695 CX761238 CX761943 XM_005272250 XP_005272307 XM_005272253 XP_005272310 XM_005272254 XP_005272311 XM_006713852 XP_006713915 XM_011513381 XP_011511683 XM_011513382 XP_011511684 XM_011513383 XP_011511685 XM_011513384 XP_011511686 XM_011513385 XP_011511687 NM_006315 NP_006306 |
Function | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:21282530}. |
Top Pathways | Signaling pathways regulating pluripotency of stem cells |
PCGF3 CRISPR/Cas9 KO Plasmid (h) - sc-405260 from Santa Cruz Biotechnology
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PCGF3 HDR Plasmid (h) - sc-405260-HDR from Santa Cruz Biotechnology
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PCGF3 Double Nickase Plasmid (h) - sc-405260-NIC from Santa Cruz Biotechnology
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PCGF3 Double Nickase Plasmid (h2) - sc-405260-NIC-2 from Santa Cruz Biotechnology
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PCGF3 CRISPR Activation Plasmid (h) - sc-405260-ACT from Santa Cruz Biotechnology
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PCGF3 CRISPR Activation Plasmid (h2) - sc-405260-ACT-2 from Santa Cruz Biotechnology
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PCGF3 Lentiviral Activation Particles (h) - sc-405260-LAC from Santa Cruz Biotechnology
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PCGF3 Lentiviral Activation Particles (h2) - sc-405260-LAC-2 from Santa Cruz Biotechnology
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PCGF3 siRNA (h) - sc-89157 from Santa Cruz Biotechnology
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PCGF3 shRNA Plasmid (h) - sc-89157-SH from Santa Cruz Biotechnology
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PCGF3 shRNA (h) Lentiviral Particles - sc-89157-V from Santa Cruz Biotechnology
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PCGF3 RNAi - H00010336-R01 from Novus Biologicals
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MISSION® esiRNA - EHU077031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16473 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16473 from Sigma-Aldrich
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PCGF3 siRNA (Human) - CRH7008 from Cohesion Biosciences
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shRNA set against Human PCGF3 (NM_006315.4) - SHH371824 from Creative biogene
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shRNA set against Human PCGF3(NM_006315.4) - SHR096708 from Creative biogene
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PCGF3 shRNA Plasmid (Human) - CHH7008 from Cohesion Biosciences
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PCGF3 miRNA 3'UTR clone - MiUTR1H-07661 from Creative biogene
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