ICA1

Gene Symbol ICA1
Entrez Gene 3382
Alt Symbol ICA69, ICAp69
Species Human
Gene Type protein-coding
Description islet cell autoantigen 1, 69kDa
Other Description 69 kDa islet cell autoantigen|diabetes mellitus type I autoantigen|islet cell autoantigen 1|islet cell autoantigen 1 isoform|islet cell autoantigen p69|p69
Swissprots Q96HG3 Q13824 P78506 Q05084 B3FTQ2 A8K7U1
Accessions AAB19035 AAB94737 AAB94738 AAD50515 AAF20020 AAF20021 CAY55971 CAY55972 EAW93610 EAW93611 EAW93612 EAW93613 EAW93614 EAW93615 EAW93616 EAW93617 EAW93618 EAW93619 EAW93620 Q05084 AA581444 AI346099 AK292106 BAF84795 AM393016 CAL37894 BC005922 BC008640 AAH08640 BM716117 BU728575 DA076379 DA154134 DB010744 DB040266 DQ891505 ABM82431 EU176613 ABW03414 EU416199 ACB47390 L01100 AAA02564 L21181 AAA64927 U26591 AAB19033 U26592 AAB19034 U37183 AAC50935 U38260 AAC50936 XM_005249735 XP_005249792 XM_011515345 XP_011513647 XM_011515346 XP_011513648 XM_011515347 XP_011513649 XM_011515348 XP_011513650 XM_011515349 XP_011513651 XM_011515350 XP_011513652 XM_011515351 XP_011513653 XM_011515352 XP_011513654 XM_011515353 XP_011513655 XM_011515354 XP_011513656 XM_011515355 XP_011513657 XM_011515356 XP_011513658 XM_011515357 XP_011513659 XR_926934 XR_926935 NM_001136020 NP_001129492 NM_001276478 NP_001263407 NM_004968 NP_004959 NM_022307 NP_071682 NM_022308
Function May play a role in neurotransmitter secretion. {ECO:0000250}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:12682071}. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.
Tissue Specificity Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid.
Top Pathways Type I diabetes mellitus

ICA69 (A-1) - sc-271489 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ICA69 (A-1): sc-271489. Western blot analysis of ICA69 expression in mouse pancreas tissue extract.

ICA69 (H-46) - sc-98858 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ICA69 (C-20) - sc-27536 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ICA69 (C-20): sc-27536. Western blot analysis of ICA69 expression in MIA PaCa-2 whole cell lysate.

ICA69 (D-14) - sc-27535 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ICA69 (D-14): sc-27535. Western blot analysis of ICA69 expression in non-transfected: sc-117752 (A) and mouse ICA69 transfected: sc-120935 (B) 293T whole cell lysates.

ICA69 (LIV3D3) - sc-53362 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ICA69 (LIV3D3): sc-53362. Western blot analysis of ICA69 expression in human pancreas tissue extract (A) and MIA PaCa-2 whole cell lysate (B).

Anti-ICA1 antibody - ab130367 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ICA1 antibody (ab130367) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

Anti-ICA1 antibody - ab55253 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55253 ICA1 antibody at 1ug/ml.

Anti-ICA69 / ICA1 Antibody (aa84-111, APC) - LS-C258977 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody (aa84-111, FITC) - LS-C258978 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody (aa84-111, Azide-free, HRP) - LS-C258980 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody (aa84-111, PE) - LS-C258981 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody (aa84-111, AP) - LS-C259893 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody - LS-C285721 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody (aa1-258, FITC) - LS-C304664 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody - LS-C310677 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody (aa1-258, Biotin) - LS-C300899 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody (aa1-257, FITC) - LS-C303948 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody (aa1-257, Biotin) - LS-C299743 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody - LS-C314283 from LifeSpan Bioscience

Prices $415.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-ICA69 / ICA1 Antibody (FITC) - LS-C317079 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody (HRP) - LS-C317081 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody (Biotin) - LS-C317080 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody (aa83-111) - LS-C322140 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ICA69 / ICA1 Antibody (aa84-111) - LS-C165103 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICA1 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The ICA1 antibody detected the ICA1 protein (arrow).

Anti-ICA69 / ICA1 Antibody (aa1-257) - LS-C294949 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant ICA69 / ICA1.
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