Gene Symbol | CHRM4 |
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Entrez Gene | 1132 |
Alt Symbol | HM4, M4R |
Species | Human |
Gene Type | protein-coding |
Description | cholinergic receptor, muscarinic 4 |
Other Description | acetylcholine receptor, muscarinic 4|muscarinic acetylcholine receptor M4 |
Swissprots | B2RPP4 P08173 Q4VBK7 Q0VD60 |
Accessions | AAA51571 BAC05815 CAA33336 EAW68004 P08173 AF385590 AAK68115 AF498918 AAM18941 BC095546 AAH95546 BC119775 AAI19776 BC119817 AAI19818 BC137535 AAI37536 BF724332 BQ322895 NM_000741 NP_000732 |
Function | The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
Top Pathways | Regulation of actin cytoskeleton, Neuroactive ligand-receptor interaction |
mAChR M4 CRISPR/Cas9 KO Plasmid (h) - sc-402318 from Santa Cruz Biotechnology
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mAChR M4 HDR Plasmid (h) - sc-402318-HDR from Santa Cruz Biotechnology
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mAChR M4 Double Nickase Plasmid (h) - sc-402318-NIC from Santa Cruz Biotechnology
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mAChR M4 Double Nickase Plasmid (h2) - sc-402318-NIC-2 from Santa Cruz Biotechnology
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mAChR M4 CRISPR Activation Plasmid (h) - sc-402318-ACT from Santa Cruz Biotechnology
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mAChR M4 CRISPR Activation Plasmid (h2) - sc-402318-ACT-2 from Santa Cruz Biotechnology
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mAChR M4 Lentiviral Activation Particles (h) - sc-402318-LAC from Santa Cruz Biotechnology
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mAChR M4 Lentiviral Activation Particles (h2) - sc-402318-LAC-2 from Santa Cruz Biotechnology
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mAChR M4 siRNA (h) - sc-42026 from Santa Cruz Biotechnology
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mAChR M4 shRNA Plasmid (h) - sc-42026-SH from Santa Cruz Biotechnology
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mAChR M4 shRNA (h) Lentiviral Particles - sc-42026-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN6094 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6094 from Sigma-Aldrich
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CHRM4 siRNA (Human) - CRH0809 from Cohesion Biosciences
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Muscarinic Acetylcholine Receptor M4/CHRM4 RNAi - H00001132-R02 from Novus Biologicals
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CHRM4 - MBS8217159 from MyBioSource
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shRNA set against Human CHRM4 (NM_000741.2) - SHH263477 from Creative biogene
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shRNA set against Human CHRM4(NM_000741.2) - SHG176883 from Creative biogene
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CHRM4 shRNA Plasmid (Human) - CHH0809 from Cohesion Biosciences
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CHRM4 miRNA 3'UTR clone - MiUTR1H-02140 from Creative biogene
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