Gene Symbol | PLXNA3 |
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Entrez Gene | 55558 |
Alt Symbol | 6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6 |
Species | Human |
Gene Type | protein-coding |
Description | plexin A3 |
Other Description | Sex chromosome X transmembrane protein of HGF receptor family 3|plexin-4|plexin-A3|semaphorin receptor SEX |
Swissprots | P51805 Q5HY36 |
Accessions | CCQ43552 EAW72702 EAW72703 P51805 AW001914 BC156373 AAI56374 BC172494 AAI72494 BF798844 BG820285 BQ718472 BQ720233 CB528571 CD365141 CD628272 CN427843 CN427844 CN427848 CN484803 HY098587 HY158513 X74609 X87197 X87852 CAA61132 XM_005274705 XP_005274762 XM_005274706 XP_005274763 XM_006724829 XP_006724892 XM_011531183 XP_011529485 XR_430556 XR_938509 XR_938510 NM_017514 NP_059984 |
Function | Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
Top Pathways | Axon guidance |
Plexin A3 (D2G12) Rabbit mAb - 5512 from Cell Signaling Technology
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plexin-A3 (A-8) - sc-374662 from Santa Cruz Biotechnology
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plexin-A3 (H-90) - sc-25641 from Santa Cruz Biotechnology
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plexin-A3 (K-15) - sc-10135 from Santa Cruz Biotechnology
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plexin-A3 (V-15) - sc-10134 from Santa Cruz Biotechnology
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Anti-Plexin A3 antibody - ab41564 from Abcam
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Anti-Plexin A3 antibody - ab191214 from Abcam
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Anti-PLXNA3 / Plexin A3 Antibody (aa34-150) - LS-C38284 from LifeSpan Bioscience
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Plexin A3 Antibody - H00055558-A01 from Novus Biologicals
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Plexin A3 Polyclonal Antibody - bs-11934R from Bioss
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Plexin A3 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11934R-A350 from Bioss
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Plexin A3 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11934R-A488 from Bioss
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Plexin A3 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11934R-A555 from Bioss
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Plexin A3 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11934R-A647 from Bioss
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Plexin A3 Polyclonal Antibody, Cy3 Conjugated - bs-11934R-Cy3 from Bioss
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Plexin A3 Polyclonal Antibody, Cy5 Conjugated - bs-11934R-Cy5 from Bioss
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Plexin A3 Polyclonal Antibody, Cy5.5 Conjugated - bs-11934R-Cy5.5 from Bioss
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Plexin A3 Polyclonal Antibody, Cy7 Conjugated - bs-11934R-Cy7 from Bioss
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Plexin A3 Polyclonal Antibody, FITC Conjugated - bs-11934R-FITC from Bioss
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Plexin A3 Polyclonal Antibody, Biotin Conjugated - bs-11934R-Biotin from Bioss
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Plexin A3 Polyclonal Antibody, HRP Conjugated - bs-11934R-HRP from Bioss
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Mouse/Rat Plexin A3 Antibody - AF4075 from R&D Systems
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Mouse/Rat Plexin A3 Affinity Purified Polyclonal Ab, Goat IgG - AF4075-SP from R&D Systems
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Plexin A3 antibody - H00055558-A01 from Acris Antibodies
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PLXNA3 Antibody - 40206 from Signalway Antibody
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