PLXNA3

Gene Symbol PLXNA3
Entrez Gene 55558
Alt Symbol 6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6
Species Human
Gene Type protein-coding
Description plexin A3
Other Description Sex chromosome X transmembrane protein of HGF receptor family 3|plexin-4|plexin-A3|semaphorin receptor SEX
Swissprots P51805 Q5HY36
Accessions CCQ43552 EAW72702 EAW72703 P51805 AW001914 BC156373 AAI56374 BC172494 AAI72494 BF798844 BG820285 BQ718472 BQ720233 CB528571 CD365141 CD628272 CN427843 CN427844 CN427848 CN484803 HY098587 HY158513 X74609 X87197 X87852 CAA61132 XM_005274705 XP_005274762 XM_005274706 XP_005274763 XM_006724829 XP_006724892 XM_011531183 XP_011529485 XR_430556 XR_938509 XR_938510 NM_017514 NP_059984
Function Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Top Pathways Axon guidance

plexin-A3 CRISPR/Cas9 KO Plasmid (h) - sc-404558 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

plexin-A3 HDR Plasmid (h) - sc-404558-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

plexin-A3 Double Nickase Plasmid (h) - sc-404558-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

plexin-A3 Double Nickase Plasmid (h2) - sc-404558-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

plexin-A3 CRISPR Activation Plasmid (h) - sc-404558-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

plexin-A3 CRISPR Activation Plasmid (h2) - sc-404558-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

plexin-A3 Lentiviral Activation Particles (h) - sc-404558-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

plexin-A3 Lentiviral Activation Particles (h2) - sc-404558-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

plexin-A3 siRNA (h) - sc-42174 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

plexin-A3 shRNA Plasmid (h) - sc-42174-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

plexin-A3 shRNA (h) Lentiviral Particles - sc-42174-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Plexin A3 RNAi - H00055558-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN17011 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

PLXNA3 siRNA (Human) - CRJ0739 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PLXNA3 (NM_017514.3) - SHH378212 from Creative biogene

Category siRNA
Species Reactivities Human

Human PLXNA3 siRNA - orb271240 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PLXNA3 shRNA Plasmid (Human) - CHJ0739 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PLXNA3 miRNA 3'UTR clone - MiUTR3H-02501 from Creative biogene

Species Reactivities Human
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