| Gene Symbol |
PLXNA3
|
| Entrez Gene |
55558
|
| Alt Symbol |
6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plexin A3
|
| Other Description |
Sex chromosome X transmembrane protein of HGF receptor family 3|plexin-4|plexin-A3|semaphorin receptor SEX
|
| Swissprots |
P51805 Q5HY36
|
| Accessions |
CCQ43552 EAW72702 EAW72703 P51805 AW001914 BC156373 AAI56374 BC172494 AAI72494 BF798844 BG820285 BQ718472 BQ720233 CB528571 CD365141 CD628272 CN427843 CN427844 CN427848 CN484803 HY098587 HY158513 X74609 X87197 X87852 CAA61132 XM_005274705 XP_005274762 XM_005274706 XP_005274763 XM_006724829 XP_006724892 XM_011531183 XP_011529485 XR_430556 XR_938509 XR_938510 NM_017514 NP_059984
|
| Function |
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Top Pathways |
Axon guidance
|