| Gene Symbol |
WWP2
|
| Entrez Gene |
11060
|
| Alt Symbol |
AIP2, WWp2-like
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WW domain containing E3 ubiquitin protein ligase 2
|
| Other Description |
NEDD4-like E3 ubiquitin-protein ligase WWP2|atrophin-1 interacting protein 2
|
| Swissprots |
H3BRF3 B2R706 O00308 Q96CZ2 Q9BWN6 F5H213 I3RSG8 B4DTL5 Q6ZTQ5 A6NEP1
|
| Accessions |
EAW83287 EAW83288 EAW83289 O00308 AI494370 AI635734 AJ001982 AK126332 BAC86528 AK295070 BAG58117 AK295701 BAG58549 AK300266 BAG62027 AK312792 BAG35653 AK316097 BAH14468 AL527115 AL583085 BC000108 AAH00108 BC013645 AAH13645 BC064531 AAH64531 BQ183829 BU167468 BX372347 DB288556 DC402912 DQ891174 ABM82100 DQ894356 ABM85282 JN712744 AFK29253 U96114 AAC51325 XM_011522823 XP_011521125 XM_011522824 XP_011521126 XM_011522825 XP_011521127 XM_011522826 XP_011521128 NM_001270453 NP_001257382 NM_001270454 NP_001257383 NM_001270455 NP_001257384 NM_007014 NP_008945 NM_199424 NP_955456
|
| Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation- induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. {ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:19651900}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:20858735}.
|
| Tissue Specificity |
Detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. Also detected in spleen and peripheral blood leukocytes. {ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:9647693}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|