WWP2

Gene Symbol	WWP2
Entrez Gene	11060
Alt Symbol	AIP2, WWp2-like
Species	Human
Gene Type	protein-coding
Description	WW domain containing E3 ubiquitin protein ligase 2
Other Description	NEDD4-like E3 ubiquitin-protein ligase WWP2|atrophin-1 interacting protein 2
Swissprots	H3BRF3 B2R706 O00308 Q96CZ2 Q9BWN6 F5H213 I3RSG8 B4DTL5 Q6ZTQ5 A6NEP1
Accessions	EAW83287 EAW83288 EAW83289 O00308 AI494370 AI635734 AJ001982 AK126332 BAC86528 AK295070 BAG58117 AK295701 BAG58549 AK300266 BAG62027 AK312792 BAG35653 AK316097 BAH14468 AL527115 AL583085 BC000108 AAH00108 BC013645 AAH13645 BC064531 AAH64531 BQ183829 BU167468 BX372347 DB288556 DC402912 DQ891174 ABM82100 DQ894356 ABM85282 JN712744 AFK29253 U96114 AAC51325 XM_011522823 XP_011521125 XM_011522824 XP_011521126 XM_011522825 XP_011521127 XM_011522826 XP_011521128 NM_001270453 NP_001257382 NM_001270454 NP_001257383 NM_001270455 NP_001257384 NM_007014 NP_008945 NM_199424 NP_955456
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation- induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. {ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:19651900}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:20858735}.
Tissue Specificity	Detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. Also detected in spleen and peripheral blood leukocytes. {ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:9647693}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Wwp2 full length protein - ab140576 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human Wwp2 full length protein - ab161272 from Abcam Category Protein Source Wheat germ Species Human

Human Wwp2 protein fragment - ab161273 from Abcam Category Protein Source Wheat germ Species Human

WWP2 Antibody Blocking Peptide - LS-E15859 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WWP2 Antibody Blocking Peptide - LS-E15860 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WWP2 Antibody Blocking Peptide - LS-E15861 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human WWP2 Protein - H00011060-Q01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human WWP2 Protein - H00011060-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human WWP2 protein (GST Tag) - orb139881 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

WWP2 Blocking Peptide - 33R-3918 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WWP2 Blocking Peptide - 33R-9153 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WWP2 Blocking Peptide - 33R-8788 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WWP2 Blocking Peptide - 33R-2586 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WWP2 - H00011060-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

WWP2 - H00011060-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

WWP2 - H00011060-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

WWP2 - H00011060-Q01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

WWP2 - H00011060-Q01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

WWP2 fusion protein - Ag2835 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human WWP2, His & GST tagged - WWP2-7349H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human WWP2, GST-tagged - WWP2-240H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human WWP2, GST-tagged - WWP2-3747H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2) - RPL087Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Human WWP2 Protein (His & GST Tag) - 13125-H20B-100 from Sino Biological Category Protein Prices $348.00, $348.00 Sizes 20 µg, 100 µg Source Baculovirus-Insect Cells Species Human

Recombinant WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2) - RPL087Hu01 from Cloud-clone Category Protein Source E.coli Species Human

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