TMEM59

Gene Symbol TMEM59
Entrez Gene 9528
Alt Symbol C1orf8, DCF1, HSPC001, PRO195, UNQ169
Species Human
Gene Type protein-coding
Description transmembrane protein 59
Other Description dendritic cell factor 1|liver membrane-bound protein
Swissprots B3KQL7 Q5T705 Q96KX7 O75393 Q9BXS4 Q4VBP9
Accessions CAF86476 CAI72163 EAX06704 EAX06705 EAX06706 EAX06707 EAX06708 EAX06709 EAX06710 EAX06711 Q9BXS4 AF047439 AAC39890 AF086356 AF290615 AAK28026 AK027328 AK057652 AK074636 AK075187 BAG52079 AK075505 BAC11658 AK123445 AK124967 AK129688 BAC85219 AK225624 AX775907 CAE11653 AX775909 CAE11654 AY359029 AAQ89388 BC003106 AAH03106 BC016374 AAH16374 BC062738 AAH62738 BC095464 AAH95464 BF574560 BI604139 BM979433 BP371330 BU165003 BX463615 CA776407 DB459209 JF432795 ADZ16012 XM_005271350 XP_005271407 XM_005271351 XP_005271408 XM_006711051 XP_006711114 NM_001305043 NP_001291972 NM_001305049 NP_001291978 NM_001305050 NP_001291979 NM_001305051 NP_001291980 NM_001305052 NP_001291981 NM_001305066 NP_001291995 NM_004872 NP_004863
Function Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. {ECO:0000269|PubMed:20427278, ECO:0000269|PubMed:23376921}.
Subcellular Location Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded.

TMEM59 (K-15) - sc-241063 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TMEM59 (S-12) - sc-241062 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TMEM59 antibody - ab105417 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of TMEM59 in Human kidney tissue with ab105417 at 20 ug/mL.

Anti-TMEM59 Antibody (aa16-311) - LS-C185624 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
TMEM59 antibody detects TMEM59 protein at cytosol on U87 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded U87 xenograft. TMEM59 antibody dilution:1:500.

Anti-TMEM59 Antibody (N-Terminus) - LS-C115931 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of TMEM59 in human kidney tissue with TMEM59 antibody at 20 ug/ml.

TMEM59 Antibody - NBP1-32303 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TMEM59 Antibody - NBP1-76497 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Transmembrane protein 59 Antibody [NBP1-76497] - Human kidney tissue lysate with TMEM59 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

TMEM59 Polyclonal Antibody - bs-11647R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TMEM59 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11647R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TMEM59 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11647R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TMEM59 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11647R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TMEM59 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11647R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TMEM59 Polyclonal Antibody, Cy3 Conjugated - bs-11647R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TMEM59 Polyclonal Antibody, Cy5 Conjugated - bs-11647R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TMEM59 Polyclonal Antibody, Cy5.5 Conjugated - bs-11647R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TMEM59 Polyclonal Antibody, Cy7 Conjugated - bs-11647R-Cy7 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TMEM59 Polyclonal Antibody, FITC Conjugated - bs-11647R-FITC from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TMEM59 Polyclonal Antibody, Biotin Conjugated - bs-11647R-Biotin from Bioss

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TMEM59 Polyclonal Antibody, HRP Conjugated - bs-11647R-HRP from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TMEM59 (301-315) antibody produced in rabbit - SAB1104416 from Sigma-Aldrich

Prices $285.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human TMEM59 was separated on SDS-PAGE, blotted with Anti-TMEM59 (301-315) (<B>Cat. No. SAB1104416</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000 <BR/>2. Antibody dilution 1:1,000 + TMEM59 immunizing peptide (human, 301-315)

Anti-TMEM59 antibody produced in rabbit - SAB3500591 from Sigma-Aldrich

Prices $346.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-TMEM59: <B>Cat. No. SAB3500591</B>: TMEM59 in human kidney tissue lysate with TMEM59 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.

Anti-TMEM59 antibody produced in rabbit - HPA007410 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TMEM59: <B>Cat. No. HPA007410</B>: Immunohistochemical staining of human soft tissue shows distinct positivity in endothelial cells.

Anti-TMEM59 (191-203) antibody produced in rabbit - SAB1104415 from Sigma-Aldrich

Prices $285.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human TMEM59 was separated on SDS-PAGE, blotted with Anti-TMEM59 (191-203) (<B>Cat. No. SAB1104415</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000

Anti-TMEM59 antibody produced in rabbit - SAB2701998 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TMEM59: <B>Cat. No. SAB2701998</B>: Immunohistochemical analysis of paraffin-embedded Mouse lung, using TMEM59 antibody at a 1:500 dilution.

TMEM59 antibody - orb75529 from Biorbyt

Prices $723.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of human kidney tissue lysate at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide using TMEM59 antibody
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