TMEM59

Gene Symbol	TMEM59
Entrez Gene	9528
Alt Symbol	C1orf8, DCF1, HSPC001, PRO195, UNQ169
Species	Human
Gene Type	protein-coding
Description	transmembrane protein 59
Other Description	dendritic cell factor 1|liver membrane-bound protein
Swissprots	B3KQL7 Q5T705 Q96KX7 O75393 Q9BXS4 Q4VBP9
Accessions	CAF86476 CAI72163 EAX06704 EAX06705 EAX06706 EAX06707 EAX06708 EAX06709 EAX06710 EAX06711 Q9BXS4 AF047439 AAC39890 AF086356 AF290615 AAK28026 AK027328 AK057652 AK074636 AK075187 BAG52079 AK075505 BAC11658 AK123445 AK124967 AK129688 BAC85219 AK225624 AX775907 CAE11653 AX775909 CAE11654 AY359029 AAQ89388 BC003106 AAH03106 BC016374 AAH16374 BC062738 AAH62738 BC095464 AAH95464 BF574560 BI604139 BM979433 BP371330 BU165003 BX463615 CA776407 DB459209 JF432795 ADZ16012 XM_005271350 XP_005271407 XM_005271351 XP_005271408 XM_006711051 XP_006711114 NM_001305043 NP_001291972 NM_001305049 NP_001291978 NM_001305050 NP_001291979 NM_001305051 NP_001291980 NM_001305052 NP_001291981 NM_001305066 NP_001291995 NM_004872 NP_004863
Function	Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. {ECO:0000269|PubMed:20427278, ECO:0000269|PubMed:23376921}.
Subcellular Location	Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TMEM59 full length protein - ab160532 from Abcam Category Protein Source Wheat germ Species Human

TMEM59 Antibody Blocking Peptide - LS-E31035 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TMEM59 Recombinant Protein - H00009528-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

TMEM59 Blocking Peptide - NBP1-76497PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human TMEM59 Protein - H00009528-G01-10ug from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Species Human

TMEM59 - H00009528-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

TMEM59 control peptide - AP26305CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TMEM59 Peptide - 6063P from ProSci Category Peptide Species Human

TMEM59 fusion protein - ag21150 from Proteintech Group Category Protein Source E. coli-derived, PET30a Species Human

TMEM59 fusion protein - ag7997 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

TMEM59 fusion protein - ag1968 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Transmembrane protein 59(TMEM59) - CSB-YP023860HU CSB-EP023860HU CSB-BP023860HU CSB-MP023860HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TMEM59 - TP305624 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

TMEM59 Recombinant Protein Antigen - NBP2-48509PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

TMEM59 Peptide, Human - M34GP16257H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Transmembrane protein 59(TMEM59) - CSB-CF023860HU from Cusabio Category Protein Source in vitro E.coli expression system Species Human

TMEM59 Recombinant Protein (Human) (OPCA05315) - OPCA05315 from Aviva Systems Biology Category Protein Species Human

Human TMEM59 protein - orb419242 from Biorbyt Category Protein Species Human

Recombinant Human TMEM59 Protein (37-323 aa), His-tagged - TMEM59-2717H from Creative Biomart Category Protein Source E. coli Cell Free Species Human

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