| Gene Symbol |
TMEM59
|
| Entrez Gene |
9528
|
| Alt Symbol |
C1orf8, DCF1, HSPC001, PRO195, UNQ169
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transmembrane protein 59
|
| Other Description |
dendritic cell factor 1|liver membrane-bound protein
|
| Swissprots |
B3KQL7 Q5T705 Q96KX7 O75393 Q9BXS4 Q4VBP9
|
| Accessions |
CAF86476 CAI72163 EAX06704 EAX06705 EAX06706 EAX06707 EAX06708 EAX06709 EAX06710 EAX06711 Q9BXS4 AF047439 AAC39890 AF086356 AF290615 AAK28026 AK027328 AK057652 AK074636 AK075187 BAG52079 AK075505 BAC11658 AK123445 AK124967 AK129688 BAC85219 AK225624 AX775907 CAE11653 AX775909 CAE11654 AY359029 AAQ89388 BC003106 AAH03106 BC016374 AAH16374 BC062738 AAH62738 BC095464 AAH95464 BF574560 BI604139 BM979433 BP371330 BU165003 BX463615 CA776407 DB459209 JF432795 ADZ16012 XM_005271350 XP_005271407 XM_005271351 XP_005271408 XM_006711051 XP_006711114 NM_001305043 NP_001291972 NM_001305049 NP_001291978 NM_001305050 NP_001291979 NM_001305051 NP_001291980 NM_001305052 NP_001291981 NM_001305066 NP_001291995 NM_004872 NP_004863
|
| Function |
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. {ECO:0000269|PubMed:20427278, ECO:0000269|PubMed:23376921}.
|
| Subcellular Location |
Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded.
|
![Western Blot: Transmembrane protein 59 Overexpression Lysate (Adult Normal) [NBL1-17093] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Transmembrane protein 59.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9369_Transmembrane%2520protein%252059%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17093-img0002.jpg)