| Gene Symbol | Dyrk2 |
|---|---|
| Entrez Gene | 69181 |
| Alt Symbol | 1810038L18Rik |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 |
| Other Description | dual specificity tyrosine-phosphorylation-regulated kinase 2|dyrk2 |
| Swissprots | Q5U4C9 |
| Accessions | EDL24384 Q5U4C9 AK007736 AK149371 AK155496 BC085145 AAH85145 XM_006514046 XP_006514109 XM_011243552 XP_011241854 NM_001014390 NP_001014412 |
| Function | Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser- 641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:20167603}. Nucleus {ECO:0000250|UniProtKB:Q92630}. Note=Translocates into the nucleus following DNA damage. {ECO:0000250|UniProtKB:Q92630}. |
dual-specificity tyrosine- (Y) -phosphorylation regulated kinase 2, ELISA Kit - MBS9320534 from MyBioSource
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Mouse Dyrk2 ELISA Kit - E051352 from Biobool
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Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 (DYRK2), ELISA Kit - MBS9397122 from MyBioSource
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Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 (DYRK2), ELISA Kit - MBS9397129 from MyBioSource
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Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2 (DYRK2), ELISA Kit - MBS9397115 from MyBioSource
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