Dyrk2

Gene Symbol Dyrk2
Entrez Gene 69181
Alt Symbol 1810038L18Rik
Species Mouse
Gene Type protein-coding
Description dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Other Description dual specificity tyrosine-phosphorylation-regulated kinase 2|dyrk2
Swissprots Q5U4C9
Accessions EDL24384 Q5U4C9 AK007736 AK149371 AK155496 BC085145 AAH85145 XM_006514046 XP_006514109 XM_011243552 XP_011241854 NM_001014390 NP_001014412
Function Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser- 641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required
Subcellular Location Cytoplasm {ECO:0000269|PubMed:20167603}. Nucleus {ECO:0000250|UniProtKB:Q92630}. Note=Translocates into the nucleus following DNA damage. {ECO:0000250|UniProtKB:Q92630}.

Mouse-Dyrk2-Antibody-C-term-Blocking-peptide - BP14070b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg
Species Mouse

Recombinant Mouse Dual specificity tyrosine-phosphorylation-regulated kinase 2(D - CSB-YP729255MO CSB-EP729255MO CSB-BP729255MO CSB-MP729255MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Recombinant Mouse DYRK2 Protein - DYRK2-4923M from Creative Biomart

Category Protein
Source Mammalian Cells
Species Mouse

Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Dyrk2), Recombinant Protein - MBS1375376 from MyBioSource

Category Protein
Prices $1,845.00, $2,000.00, $2,185.00, $2,300.00, $2,495.00, $2,500.00, $2,885.00, $3,095.00, $3,640.00, $4,545.00
Sizes 50 µg (Baculovirus), 500 µg (E-Coli), 500 µg (Yeast), 100 µg (Baculovirus), 1 mg (E-Coli), 50 µg (Mammalian-Cell), 1 mg (Yeast), 100 µg (Mammalian-Cell), 500 µg (Baculovirus), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse
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