Dyrk2

Gene Symbol Dyrk2
Entrez Gene 69181
Alt Symbol 1810038L18Rik
Species Mouse
Gene Type protein-coding
Description dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Other Description dual specificity tyrosine-phosphorylation-regulated kinase 2|dyrk2
Swissprots Q5U4C9
Accessions EDL24384 Q5U4C9 AK007736 AK149371 AK155496 BC085145 AAH85145 XM_006514046 XP_006514109 XM_011243552 XP_011241854 NM_001014390 NP_001014412
Function Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser- 641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required
Subcellular Location Cytoplasm {ECO:0000269|PubMed:20167603}. Nucleus {ECO:0000250|UniProtKB:Q92630}. Note=Translocates into the nucleus following DNA damage. {ECO:0000250|UniProtKB:Q92630}.

Dyrk2 CRISPR/Cas9 KO Plasmid (m) - sc-427328 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dyrk2 HDR Plasmid (m) - sc-427328-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dyrk2 Double Nickase Plasmid (m) - sc-427328-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dyrk2 Double Nickase Plasmid (m2) - sc-427328-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dyrk2 CRISPR Activation Plasmid (m) - sc-427328-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dyrk2 CRISPR Activation Plasmid (m2) - sc-427328-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dyrk2 Lentiviral Activation Particles (m) - sc-427328-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dyrk2 Lentiviral Activation Particles (m2) - sc-427328-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Dyrk2 siRNA (m) - sc-44588 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Dyrk2 shRNA Plasmid (m) - sc-44588-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Dyrk2 shRNA (m) Lentiviral Particles - sc-44588-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU163511 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® Long Non-Coding esiRNA - EMNC004681 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN30339 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30339 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DYRK2 siRNA (Mouse) - CRM7902 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

DYRK2 - MBS8241395 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse DYRK2 (NM_001014390.2) - SHH282296 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Dyrk2(NM_001014390.2) - SHH020891 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse DYRK2 siRNA - orb287378 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

DYRK2 shRNA Plasmid (Mouse) - CHM7902 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

DYRK2 miRNA 3'UTR clone - MiUTR1M-04082 from Creative biogene

Species Reactivities Mouse
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