Gene Symbol | PSMG1 |
---|---|
Entrez Gene | 8624 |
Alt Symbol | C21LRP, DSCR2, LRPC21, PAC-1, PAC1 |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) assembly chaperone 1 |
Other Description | Down syndrome critical region gene 2|Down syndrome critical region protein 2|chromosome 21 leucine-rich protein|leucine rich protein C21-LRP|proteasome assembling chaperone 1|proteasome assembly chaperone 1 |
Swissprots | Q6FHD3 B5BUN2 Q6FHA3 O95456 Q6S713 |
Accessions | CAB90451 EAX09664 EAX09665 EAX09666 O95456 AA731200 AB451468 BAG70282 AF417108 AJ006291 CAA06957 AK001455 AK308614 AK315406 BAG37798 AW594615 AY463963 AAR25628 BC003619 AAH03619 BC010424 AAH10424 BC011755 AAH11755 BC012809 AAH12809 BE779375 BM013494 BM460414 BM462074 BM476420 BQ008489 BR000236 FAA00022 CB160221 CR541821 CAG46620 CR541852 CAG46650 DQ892311 ABM83237 DQ895511 ABM86437 FN152980 XM_011529771 XP_011528073 NM_001261824 NP_001248753 NM_003720 NP_003711 NM_203433 NP_982257 NR_049728 |
Function | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}. |
Subcellular Location | Cytoplasm. Endoplasmic reticulum. |
Tissue Specificity | In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines. {ECO:0000269|PubMed:10872820, ECO:0000269|PubMed:9784380}. |
DSCR 2 CRISPR/Cas9 KO Plasmid (h) - sc-404157 from Santa Cruz Biotechnology
|
||||||||
DSCR 2 HDR Plasmid (h) - sc-404157-HDR from Santa Cruz Biotechnology
|
||||||||
DSCR 2 Double Nickase Plasmid (h) - sc-404157-NIC from Santa Cruz Biotechnology
|
||||||||
DSCR 2 Double Nickase Plasmid (h2) - sc-404157-NIC-2 from Santa Cruz Biotechnology
|
||||||||
DSCR 2 CRISPR Activation Plasmid (h) - sc-404157-ACT from Santa Cruz Biotechnology
|
||||||||
DSCR 2 CRISPR Activation Plasmid (h2) - sc-404157-ACT-2 from Santa Cruz Biotechnology
|
||||||||
DSCR 2 Lentiviral Activation Particles (h) - sc-404157-LAC from Santa Cruz Biotechnology
|
||||||||
DSCR 2 Lentiviral Activation Particles (h2) - sc-404157-LAC-2 from Santa Cruz Biotechnology
|
||||||||
DSCR 2 siRNA (h) - sc-91490 from Santa Cruz Biotechnology
|
||||||||
DSCR 2 shRNA Plasmid (h) - sc-91490-SH from Santa Cruz Biotechnology
|
||||||||
DSCR 2 shRNA (h) Lentiviral Particles - sc-91490-V from Santa Cruz Biotechnology
|
||||||||
PSMG1 RNAi - H00008624-R01 from Novus Biologicals
|
||||||||
PSMG1 RNAi - H00008624-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU099081 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN17633 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17633 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR00643 from Sigma-Aldrich
|
||||||||
PSMG1 siRNA (Human) - CRH5667 from Cohesion Biosciences
|
||||||||
shRNA set against Human PSMG1 (NM_003720.3) - SHH385576 from Creative biogene
|
||||||||
Human PSMG1 siRNA - orb266169 from Biorbyt
|
||||||||
PSMG1 shRNA Plasmid (Human) - CHH5667 from Cohesion Biosciences
|
||||||||
PSMG1 miRNA 3'UTR clone - MiUTR3H-07546 from Creative biogene
|
||||||||
PSMG1 miRNA 3'UTR clone - MiUTR3H-07547 from Creative biogene
|