| Gene Symbol |
PPRC1
|
| Entrez Gene |
23082
|
| Alt Symbol |
PRC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
peroxisome proliferator-activated receptor gamma, coactivator-related 1
|
| Other Description |
PGC-1-related coactivator|peroxisome proliferator-activated receptor gamma coactivator-related protein 1
|
| Swissprots |
Q9BUJ3 Q9Y4E0 Q5VV67 Q76N31 Q6P3U5 Q5VV66 Q9BZE5 Q6P3W1
|
| Accessions |
EAW49719 EAW49720 EAW49721 Q5VV67 AB011167 BAA25521 AF325193 AAK11573 AK025691 AK095248 AK299885 BAG61732 BC002561 AAH02561 BC063806 AAH63806 BC063829 AAH63829 BU742486 CA442653 HY023373 XM_005269656 XP_005269713 XM_005269658 XP_005269715 XM_006717731 XP_006717794 XM_011539549 XP_011537851 XM_011539550 XP_011537852 XM_011539551 XP_011537853 XM_011539552 XP_011537854 XM_011539553 XP_011537855 NM_001288727 NP_001275656 NM_001288728 NP_001275657 NM_015062 NP_055877
|
| Function |
Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11340167}. Note=Colocalizes with NRF1. {ECO:0000250}.
|
| Tissue Specificity |
Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:14550271}.
|