Gene Symbol | PPRC1 |
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Entrez Gene | 23082 |
Alt Symbol | PRC |
Species | Human |
Gene Type | protein-coding |
Description | peroxisome proliferator-activated receptor gamma, coactivator-related 1 |
Other Description | PGC-1-related coactivator|peroxisome proliferator-activated receptor gamma coactivator-related protein 1 |
Swissprots | Q9BUJ3 Q9Y4E0 Q5VV67 Q76N31 Q6P3U5 Q5VV66 Q9BZE5 Q6P3W1 |
Accessions | EAW49719 EAW49720 EAW49721 Q5VV67 AB011167 BAA25521 AF325193 AAK11573 AK025691 AK095248 AK299885 BAG61732 BC002561 AAH02561 BC063806 AAH63806 BC063829 AAH63829 BU742486 CA442653 HY023373 XM_005269656 XP_005269713 XM_005269658 XP_005269715 XM_006717731 XP_006717794 XM_011539549 XP_011537851 XM_011539550 XP_011537852 XM_011539551 XP_011537853 XM_011539552 XP_011537854 XM_011539553 XP_011537855 NM_001288727 NP_001275656 NM_001288728 NP_001275657 NM_015062 NP_055877 |
Function | Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:16908542}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:11340167}. Note=Colocalizes with NRF1. {ECO:0000250}. |
Tissue Specificity | Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors. {ECO:0000269|PubMed:11340167, ECO:0000269|PubMed:14550271}. |
PRC CRISPR/Cas9 KO Plasmid (h) - sc-405028 from Santa Cruz Biotechnology
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PRC HDR Plasmid (h) - sc-405028-HDR from Santa Cruz Biotechnology
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PRC Double Nickase Plasmid (h) - sc-405028-NIC from Santa Cruz Biotechnology
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PRC Double Nickase Plasmid (h2) - sc-405028-NIC-2 from Santa Cruz Biotechnology
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PRC CRISPR Activation Plasmid (h) - sc-405028-ACT from Santa Cruz Biotechnology
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PRC CRISPR Activation Plasmid (h2) - sc-405028-ACT-2 from Santa Cruz Biotechnology
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PRC Lentiviral Activation Particles (h) - sc-405028-LAC from Santa Cruz Biotechnology
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PRC Lentiviral Activation Particles (h2) - sc-405028-LAC-2 from Santa Cruz Biotechnology
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PRC siRNA (h) - sc-90572 from Santa Cruz Biotechnology
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PRC shRNA Plasmid (h) - sc-90572-SH from Santa Cruz Biotechnology
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PRC shRNA (h) Lentiviral Particles - sc-90572-V from Santa Cruz Biotechnology
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PPRC1 RNAi - H00023082-R01 from Novus Biologicals
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MISSION® esiRNA - EHU130501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17321 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01955 from Sigma-Aldrich
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PPRC1 siRNA (Human) - CRH7985 from Cohesion Biosciences
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shRNA set against Human PPRC1 (NM_015062.3) - SHH381712 from Creative biogene
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shRNA set against Human PPRC1(NM_015062.3) - SHR135872 from Creative biogene
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Human PPRC1 siRNA - orb268487 from Biorbyt
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PPRC1 shRNA Plasmid (Human) - CHH7985 from Cohesion Biosciences
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PPRC1 miRNA 3'UTR clone - MiUTR1H-08201 from Creative biogene
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