| Gene Symbol |
NEU3
|
| Entrez Gene |
10825
|
| Alt Symbol |
SIAL3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sialidase 3 (membrane sialidase)
|
| Other Description |
N-acetyl-alpha-neuraminidase 3|ganglioside sialidase|membrane sialidase|neuraminidase 3|sialidase-3
|
| Swissprots |
Q9NQE1 A8K327 Q9UQ49
|
| Accessions |
EAW74953 EAW74954 Q9UQ49 AB008185 BAA82611 AK022450 BAG51074 AK290442 BAF83131 AK303540 BAG64566 BC136397 AAI36398 BC144059 AAI44060 CN429425 DB240271 DQ590342 Y18563 CAB96131 NM_006656 NP_006647
|
| Function |
Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. {ECO:0000269|PubMed:10861246, ECO:0000269|PubMed:20511247}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:10861246}; Peripheral membrane protein {ECO:0000269|PubMed:10861246}.
|
| Tissue Specificity |
Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung. {ECO:0000269|PubMed:10861246}.
|
| Top Pathways |
Sphingolipid metabolism, Other glycan degradation
|
![Western Blot: NEU3 Overexpression Lysate (Adult Normal) [NBP2-04315] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NEU3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8738_NEU3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04315-img0001.jpg)