Gene Symbol | NEU3 |
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Entrez Gene | 10825 |
Alt Symbol | SIAL3 |
Species | Human |
Gene Type | protein-coding |
Description | sialidase 3 (membrane sialidase) |
Other Description | N-acetyl-alpha-neuraminidase 3|ganglioside sialidase|membrane sialidase|neuraminidase 3|sialidase-3 |
Swissprots | Q9NQE1 A8K327 Q9UQ49 |
Accessions | EAW74953 EAW74954 Q9UQ49 AB008185 BAA82611 AK022450 BAG51074 AK290442 BAF83131 AK303540 BAG64566 BC136397 AAI36398 BC144059 AAI44060 CN429425 DB240271 DQ590342 Y18563 CAB96131 NM_006656 NP_006647 |
Function | Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. {ECO:0000269|PubMed:10861246, ECO:0000269|PubMed:20511247}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:10861246}; Peripheral membrane protein {ECO:0000269|PubMed:10861246}. |
Tissue Specificity | Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung. {ECO:0000269|PubMed:10861246}. |
Top Pathways | Sphingolipid metabolism, Other glycan degradation |
Ganglioside sialidase CRISPR/Cas9 KO Plasmid (h) - sc-404848 from Santa Cruz Biotechnology
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Ganglioside sialidase HDR Plasmid (h) - sc-404848-HDR from Santa Cruz Biotechnology
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Ganglioside sialidase Double Nickase Plasmid (h) - sc-404848-NIC from Santa Cruz Biotechnology
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Ganglioside sialidase Double Nickase Plasmid (h2) - sc-404848-NIC-2 from Santa Cruz Biotechnology
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Ganglioside sialidase CRISPR Activation Plasmid (h) - sc-404848-ACT from Santa Cruz Biotechnology
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Ganglioside sialidase CRISPR Activation Plasmid (h2) - sc-404848-ACT-2 from Santa Cruz Biotechnology
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Ganglioside sialidase Lentiviral Activation Particles (h) - sc-404848-LAC from Santa Cruz Biotechnology
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Ganglioside sialidase Lentiviral Activation Particles (h2) - sc-404848-LAC-2 from Santa Cruz Biotechnology
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Ganglioside sialidase siRNA (h) - sc-62366 from Santa Cruz Biotechnology
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Ganglioside sialidase shRNA Plasmid (h) - sc-62366-SH from Santa Cruz Biotechnology
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Ganglioside sialidase shRNA (h) Lentiviral Particles - sc-62366-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU030731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15217 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15217 from Sigma-Aldrich
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NEU3 siRNA (Human) - CRH7377 from Cohesion Biosciences
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shRNA set against Human NEU3 (NM_006656.5) - SHH351468 from Creative biogene
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Human NEU3 siRNA - orb267879 from Biorbyt
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NEU3 shRNA Plasmid (Human) - CHH7377 from Cohesion Biosciences
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NEU3 miRNA 3'UTR clone - MiUTR1H-06725 from Creative biogene
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