| Gene Symbol |
UGT1A10
|
| Entrez Gene |
54575
|
| Alt Symbol |
UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 1 family, polypeptide A10
|
| Other Description |
UDP glycosyltransferase 1 family, polypeptide A10|UDP-glucuronosyltransferase 1-10|UDP-glucuronosyltransferase 1-J|UDP-glucuronosyltransferase 1A10|UDPGT 1-10
|
| Swissprots |
Q9HAW8 O00474 Q6NT91 Q7Z6H8
|
| Accessions |
AAA80547 AAF03522 AAG30417 EAW71058 Q9HAW8 AK025403 AY435137 AAR95638 BC020971 AAH20971 BC053576 AAH53576 BC069210 AAH69210 U89508 AAB81537 NM_019075 NP_061948
|
| Function |
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:19545173}.
|
| Subcellular Location |
Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Liver and colon. Isoform 1 and isoform 2 are expressed in colon, esophagus and small intestine; isoform 2 but not isoform 1 is expressed in liver or kidney (PubMed:18004212). {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:9271343}.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450
|