Gene Symbol | UGT1A10 |
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Entrez Gene | 54575 |
Alt Symbol | UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J |
Species | Human |
Gene Type | protein-coding |
Description | UDP glucuronosyltransferase 1 family, polypeptide A10 |
Other Description | UDP glycosyltransferase 1 family, polypeptide A10|UDP-glucuronosyltransferase 1-10|UDP-glucuronosyltransferase 1-J|UDP-glucuronosyltransferase 1A10|UDPGT 1-10 |
Swissprots | Q9HAW8 O00474 Q6NT91 Q7Z6H8 |
Accessions | AAA80547 AAF03522 AAG30417 EAW71058 Q9HAW8 AK025403 AY435137 AAR95638 BC020971 AAH20971 BC053576 AAH53576 BC069210 AAH69210 U89508 AAB81537 NM_019075 NP_061948 |
Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:19545173}. |
Subcellular Location | Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Liver and colon. Isoform 1 and isoform 2 are expressed in colon, esophagus and small intestine; isoform 2 but not isoform 1 is expressed in liver or kidney (PubMed:18004212). {ECO:0000269|PubMed:18004212, ECO:0000269|PubMed:9271343}. |
Top Pathways | Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450 |
UGT1A10 CRISPR/Cas9 KO Plasmid (h) - sc-402837 from Santa Cruz Biotechnology
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UGT1A10 HDR Plasmid (h) - sc-402837-HDR from Santa Cruz Biotechnology
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UGT1A10 Double Nickase Plasmid (h) - sc-402837-NIC from Santa Cruz Biotechnology
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UGT1A10 Double Nickase Plasmid (h2) - sc-402837-NIC-2 from Santa Cruz Biotechnology
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UGT1A10 CRISPR Activation Plasmid (h) - sc-402837-ACT from Santa Cruz Biotechnology
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UGT1A10 CRISPR Activation Plasmid (h2) - sc-402837-ACT-2 from Santa Cruz Biotechnology
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UGT1A10 Lentiviral Activation Particles (h) - sc-402837-LAC from Santa Cruz Biotechnology
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UGT1A10 Lentiviral Activation Particles (h2) - sc-402837-LAC-2 from Santa Cruz Biotechnology
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UGT1A siRNA (h) - sc-44538 from Santa Cruz Biotechnology
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UGT1A shRNA Plasmid (h) - sc-44538-SH from Santa Cruz Biotechnology
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UGT1A shRNA (h) Lentiviral Particles - sc-44538-V from Santa Cruz Biotechnology
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UGT1A10 RNAi - H00054575-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN22457 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22457 from Sigma-Aldrich
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UGT1A10 siRNA (Human) - CRJ0140 from Cohesion Biosciences
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UGT1A10 - MBS8205721 from MyBioSource
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shRNA set against Human UGT1A10 (NM_019075.2) - SHH440060 from Creative biogene
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Human UGT1A10 siRNA - orb270641 from Biorbyt
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UGT1A10 shRNA Plasmid (Human) - CHJ0140 from Cohesion Biosciences
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UGT1A10 miRNA 3'UTR clone - MiUTR1H-10989 from Creative biogene
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