CUL4B

Gene Symbol CUL4B
Entrez Gene 8450
Alt Symbol CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2
Species Human
Gene Type protein-coding
Description cullin 4B
Other Description cullin-4B
Swissprots Q9UED7 Q13620 Q9UEB7 Q6PIE4 B1APK5 Q6UP07 B3KVX4 Q7Z673 B7Z5K8 Q9BY37
Accessions AAB67315 EAX11876 EAX11877 EAX11878 EAX11879 EAX11880 Q13620 AB014595 BAA31670 AF212995 AAK16812 AK123688 BAG53936 AK299081 BAH12944 AK315037 BAG37520 AY365125 AAR13073 BC036216 AAH36216 BX537641 BX537787 CAD97843 BX647096 CR936722 CV573599 DB092748 DQ894750 ABM85676 U58091 AAC50548 XM_005262481 XP_005262538 XM_006724784 XP_006724847 XM_006724785 XP_006724848 XM_011531399 XP_011529701 XM_011531400 XP_011529702 XM_011531401 XP_011529703 NM_001079872 NP_001073341 NM_003588 NP_003579
Function Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation- induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway
Subcellular Location Nucleus {ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19801544}.
Top Pathways Ubiquitin mediated proteolysis, Nucleotide excision repair

CUL-4 (H-11) - sc-377188 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CUL-4 (H-11): sc-sc-377188. Western blot analysis of CUL-4 expression in SK-MEL-28 (A) and A-375 (B) whole cell lysates.

CUL-4 (T-15) - sc-5323 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CUL-4 (C-19) - sc-8557 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CUL-4 (C-19): sc-8557. Western blot analysis of CUL-4 expression in rat liver tissue extract.

CUL-4 (H-66) - sc-10782 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CUL-4 (H-66): sc-10782. Immunofluorescence staining of formalin-fixed HeLa cells showing nuclear and cytoplasmic localization. Kindly provided by Yang Xiang, Ph.D., Division of Newborn Medicine, Boston Childrens Hospital, Cell Biology Department, Harvard Medical School.z

Anti-Cullin 4A/B antibody [EPR3200] - ab76470 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3200
All lanes : Anti-Cullin 4A/B antibody [EPR3200] (ab76470) at 1/5000 dilutionLane 1 : Fetal uterus lysateLane 2 : Hela lysateLane 3 : A375 lysateLane 4 : Fetal testis lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Cullin 4B antibody - ab67035 from Abcam

Prices $401.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Cullin 4B antibody (ab67035) at 1/500 dilutionLane 1 : Transfected 293T cell lysateLane 2 : non Transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-Cullin 4B antibody - ab85610 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cullin 4B antibody (ab85610) at 1 µg/mlLane 1 : Female zebrafish tissue lysateLane 2 : MM453 whole cell lysateLane 3 : rat liver tissue lysateLane 4 : rat lung tissue lysateLane 5 : MCF7 whole cell lysateLane 6 : MM231 whole cell lysateLysates/proteins at 50 µg per lane.Secondary HRP-conjugated Goat anti-rabbit IgG at 1/3000 dilution

Anti-Cullin 4B antibody - ab137615 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Cullin 4B / CUL4B Antibody (clone 1C4) - LS-C175298 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 1C4
IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-CUL4B mouse monoclonal antibody.

Anti-Cullin 4B / CUL4B Antibody (Internal, clone EPR3200) IHC-plus™ - LS-B7866 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone EPR3200
Anti-Cullin 4B / CUL4B antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7866 dilution 1:25.

Anti-Cullin 4B / CUL4B Antibody (aa232-260, AP) - LS-C208711 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cullin 4B / CUL4B Antibody (aa232-260, APC) - LS-C208712 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cullin 4B / CUL4B Antibody (aa232-260, Biotin) - LS-C208713 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cullin 4B / CUL4B Antibody (aa232-260, FITC) - LS-C208714 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cullin 4B / CUL4B Antibody (aa232-260, Azide-free, HRP) - LS-C208715 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cullin 4B / CUL4B Antibody (clone 7G10) - LS-C175272 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 7G10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CUL4B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CUL4B.

Anti-Cullin 4B / CUL4B Antibody - LS-C307129 from LifeSpan Bioscience

Host Mouse
Clonality Polyclonal

Anti-Cullin 4B / CUL4B Antibody (aa232-260, PE) - LS-C208717 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cullin 4B / CUL4B Antibody - LS-C172036 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cullin 4B / CUL4B Antibody (aa232-260) - LS-C320687 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cullin 4B / CUL4B Antibody - LS-C341790 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Cullin 4B / CUL4B Antibody (aa232-260) - LS-C157669 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of CUL4B Antibody antibody pre-incubated without(lane 1) and with(lane 2) blocking peptide in HeLa cell line lysate. CUL4B Antibody (arrow) was detected using the purified antibody.

Anti-Cullin 4B / CUL4B Antibody (aa50-100) - LS-C290512 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human Cul4B by Western Blot. Samples: Whole cell lysate from 293T (15 and 50 ug), HeLa (H; 50 ug), and Jurkat (J; 50 ug) cells. Antibodies: Affinity purified rabbit anti-Cul4B antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-Cullin 4B / CUL4B Antibody (aa863-913) - LS-C290513 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human Cul4B by Western Blot. Samples: Whole cell lysate from 293T (15 and 50 ug), HeLa (50 ug), and Jurkat (50 ug) cells. Antibodies:Affinity purified rabbit anti-Cul4B antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-Cullin 4B / CUL4B Antibody - LS-C346081 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of U20S cell using CUL4B antibody.
Search more